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Cellular cyclic AMP...
Cellular cyclic AMP levels modulate insulin sensitivity and responsiveness : evidence against a significant role of Gi in insulin signal transduction
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Wesslau, C (author)
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- Eriksson, Jan W (author)
- Gothenburg University, Sahlgrens Hospital, Department of Medicine, Gothenburg, Sweden
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Smith, U (author)
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(creator_code:org_t)
- Elsevier BV, 1993
- 1993
- English.
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In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 196:1, s. 287-293
- Related links:
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https://urn.kb.se/re...
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Abstract
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- Treating rats with pertussis toxin (PTX) both elevated the adipocyte cAMP levels and impaired sensitivity and responsiveness to the antilipolytic effect of insulin in the presence of different beta-adrenergic agonists. However, in the presence of a fixed medium concentration of the degradable cAMP analogue, 8-bromo-cAMP, the effect of insulin was similar in PTX- and control cells. Elevating the cAMP levels in control cells either through different concentrations of the cAMP analogue or addition of adenosine deaminase impaired both insulin sensitivity and responsiveness to a similar extent as that seen in PTX-treated cells. The antilipolytic effect of insulin was exerted through the activation of the cGMP-inhibitable phosphodiesterase (cGI-PDE) as it was dose-dependently impaired by the specific cGI-PDE inhibitor OPC 3911. The results show the importance of the cellular cAMP levels in modulating insulin sensitivity and action. Gi plays a minor role, if any, for the signal transduction of the antilipolytic effect of insulin.
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- art (subject category)
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