SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-211337"
 

Search: onr:"swepub:oai:DiVA.org:uu-211337" > Cellular cyclic AMP...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Cellular cyclic AMP levels modulate insulin sensitivity and responsiveness : evidence against a significant role of Gi in insulin signal transduction

Wesslau, C (author)
Eriksson, Jan W (author)
Gothenburg University, Sahlgrens Hospital, Department of Medicine, Gothenburg, Sweden
Smith, U (author)
 (creator_code:org_t)
Elsevier BV, 1993
1993
English.
In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 196:1, s. 287-293
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Treating rats with pertussis toxin (PTX) both elevated the adipocyte cAMP levels and impaired sensitivity and responsiveness to the antilipolytic effect of insulin in the presence of different beta-adrenergic agonists. However, in the presence of a fixed medium concentration of the degradable cAMP analogue, 8-bromo-cAMP, the effect of insulin was similar in PTX- and control cells. Elevating the cAMP levels in control cells either through different concentrations of the cAMP analogue or addition of adenosine deaminase impaired both insulin sensitivity and responsiveness to a similar extent as that seen in PTX-treated cells. The antilipolytic effect of insulin was exerted through the activation of the cGMP-inhibitable phosphodiesterase (cGI-PDE) as it was dose-dependently impaired by the specific cGI-PDE inhibitor OPC 3911. The results show the importance of the cellular cAMP levels in modulating insulin sensitivity and action. Gi plays a minor role, if any, for the signal transduction of the antilipolytic effect of insulin.

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Wesslau, C
Eriksson, Jan W
Smith, U
Articles in the publication
Biochemical and ...
By the university
Uppsala University

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view