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Macrocylic inhibito...
Macrocylic inhibitors of hepatitis C virus
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Simmen, K. A. (author)
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De Kock, H. A. (author)
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Raboisson,, P. J. (author)
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Hu, L. (author)
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Tahri, A. (author)
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Surleraux,, D. L. N. G. (author)
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Nilsson, K. M. (author)
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Samuelsson, B. B. (author)
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Rosenquist, Å. A. K. (author)
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Ivanov, V. (author)
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Pelcman, M. (author)
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Belfrage,, Anna Karin G. L. (author)
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Johansson, P. M. (author)
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Vendeville,, S. M. H. (author)
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- 2012
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
Close
- Inhibitors of HCV replication of formula (I)and the N-oxides, salts, and stereoisomers, whereineach dashed line represents an optional double bond;X is N, CH and where X bears a double bond it is C;R1 is —OR7, —NH—SO2R8;R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl;R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl;R4 is aryl or Het; n is 3, 4, 5, or 6;R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het;R6 is C1-6alkoxy, or dimethylamino;R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;aryl is phenyl optionally substituted with one, two or three substituents;Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents;pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- Medicinal Chemistry
- Läkemedelskemi
Publication and Content Type
- pop (subject category)
- pat (subject category)
To the university's database
- By the author/editor
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Simmen, K. A.
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De Kock, H. A.
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Raboisson,, P. J ...
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Hu, L.
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Tahri, A.
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Surleraux,, D. L ...
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show more...
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Nilsson, K. M.
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Samuelsson, B. B ...
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Rosenquist, Å. A ...
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Ivanov, V.
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Pelcman, M.
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Belfrage,, Anna ...
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Johansson, P. M.
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Vendeville,, S. ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
- By the university
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Uppsala University