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A Randomized Study ...
A Randomized Study of Interferon alpha-2b Versus No Treatment as Consolidation After High Dose Therapy and Autologous Stem Cell Transplantation for Patients With Relapsed Lymphoma
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Bosly, Andre (author)
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Grigg, Andrew (author)
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Holte, Harald (author)
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Gisselbrecht, Christian (author)
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Radford, John (author)
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Rossi, Andrea (author)
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Lopez-Guillermo, Armando (author)
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Trneny, Marek (author)
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Sebban, Catherine (author)
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- Hagberg, Hans (author)
- Uppsala universitet,Enheten för onkologi
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da Costa, Fernando Leal (author)
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Colombat, Philippe (author)
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Bron, Dominique (author)
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Coiffier, Bertrand (author)
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(creator_code:org_t)
- 2013-10-08
- 2013
- English.
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In: The Oncologist. - : Oxford University Press (OUP). - 1083-7159 .- 1549-490X. ; 18:11, s. 1189-1189
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background. Patients with lymphoma who have experienced a first relapse or progression and have disease deemed sensitive to salvage chemotherapy nevertheless have a high likelihood of having a second relapse. To decrease the likelihood of a second relapse after high-dose therapy (HDT) and autologous stem cell transplantation (ASCT), interferon (IFN) alpha-2b was given in a prospective randomized international trial. Methods. In this trial, 221 patients with varying histologic diagnoses (8 small lymphocytic, 37 follicular, 9 mantle, 90 diffuse large B-cell, 20 peripheral T-cell, 3 high-grade B-cell non-Hodgkin lymphoma, and 54 Hodgkin lymphoma) were randomly assigned to receive no further treatment (armA: 117 patients) or IFN alpha-2b, 3 MU three times weekly, for 18 months (arm B: 104 patients). Results. In arm B, 21 patients (20%) did not receive IFN alpha-2b because of early progression or absence of hematologic recovery, 29 patients (28%) completed the 18 months of treatment, and 54 patients (52%) interrupted treatment because of progression (23%) or toxicity (29%). Event-free survival and overall survival were not different between the two arms on an intent-to-treat analysis and also if analysis was restricted to patients who were a live and had not experienced disease progression three months after transplantation. The study was not sufficiently powered to evaluate effects in histologic subtypes. Conclusion. In this trial, post-autograft IFN alpha-2b did not improve outcomes in a heterogeneous group of patients with lymphoma.
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- By the author/editor
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Bosly, Andre
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Grigg, Andrew
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Holte, Harald
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Gisselbrecht, Ch ...
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Radford, John
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Rossi, Andrea
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show more...
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Lopez-Guillermo, ...
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Trneny, Marek
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Sebban, Catherin ...
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Hagberg, Hans
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da Costa, Fernan ...
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Colombat, Philip ...
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Bron, Dominique
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Coiffier, Bertra ...
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show less...
- Articles in the publication
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The Oncologist
- By the university
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Uppsala University