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Octreotide and inte...
Octreotide and interferon alfa : a new combination for the treatment of malignant carcinoid tumours
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- Tiensuu Janson, Eva (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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- Ahlström, Håkan (author)
- Uppsala universitet,Enheten för radiologi
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Andersson, T (author)
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- Öberg, Kjell (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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(creator_code:org_t)
- 1992
- 1992
- English.
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In: European Journal of Cancer. - 0959-8049 .- 1879-0852. ; 28A:10, s. 1647-1650
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Subject headings
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- 24 patients with malignant carcinoid tumours received octreotide and interferon alfa (IFN-alpha). All the patients initially received octreotide 50-100 micrograms, twice daily. When progressive symptoms or increasing biochemical markers were observed, the daily dose was raised to a median 300 micrograms. If the initial dose proved ineffective or if no improvement was seen after escalation, IFN-alpha was added (median 9 MU subcutaneously per week). After the addition of IFN-alpha, 17 of the 22 patients (77%) with elevated urinary 5-hydroxyindoleacetic acid showed a significant (> 50%) reduction. Only 1 patient progressed and 4 had continuously stable biochemical disease. No significant reduction in tumour size was noted; in 5 patients, the tumour continued to grow despite decreasing hormone levels. 18 patients had carcinoid syndrome when IFN-alpha was added in 10 (56%) symptoms ameliorated. Thus, the addition of IFN-alpha is beneficial for patients with malignant carcinoid tumours that progress and/or who do not respond to octreotide.
Keyword
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
- Female
- Humans
- Hydroxyindoleacetic Acid/urine
- Interferon-alpha/therapeutic use
- Male
- Malignant Carcinoid Syndrome/mortality/*therapy/urine
- Middle Aged
- Octreotide/therapeutic use
Publication and Content Type
- ref (subject category)
- art (subject category)
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