Search: onr:"swepub:oai:DiVA.org:uu-214496" >
Tailored Doxorubici...
Tailored Doxorubicin-Hyaluronan Conjugate as a Potent Anticancer Glyco-Drug : An Alternative to Prodrug Approach
-
- Podiyan, Oommen (author)
- Uppsala universitet,Polymerkemi
-
- Garousi, Javad (author)
- Uppsala universitet,Polymerkemi
-
Sloff, Marije (author)
-
show more...
-
- Varghese, Oommen (author)
- Uppsala universitet,Polymerkemi
-
show less...
-
(creator_code:org_t)
- 2013-10-15
- 2014
- English.
-
In: Macromolecular Bioscience. - : Wiley. - 1616-5187 .- 1616-5195. ; 14:3, s. 327-333
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Releasibility of doxorubicin from drug-conjugates is believed to be a prerequisite for its anti- cancer activity. Here, a new glyco-drug approach that circumvents the releasibility restriction is reported, opening a new possibility to design efficient, target specific drug delivery system. It is discovered that stable amide coupling of doxorubicin (DOX) tohyaluronan (HA) shows dose dependent cytotoxicity to CD44 positive human coloncancer cells (HCT116) as compared to human breast cancer cells(MCF-7) and mouse fibroblast cells (NIH-3T3), which express less CD44 receptor. This direct conjugation approach is an easy scalable strategy that could be adopted to design innocuous anti-tumor nanoparticle formulations.
Subject headings
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database