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A systematic analys...
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Gremel, GabrielaUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab
(author)
A systematic analysis of commonly used antibodies in cancer diagnostics
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2013-11-05
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Wiley,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-216054
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216054URI
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https://doi.org/10.1111/his.12255DOI
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https://lup.lub.lu.se/record/4261893URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-140127URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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De två (2) första författarna delar förstaförfattarskapet.
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QC 20140122
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AimsImmunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic power of antibodies used frequently for clinical differential diagnostics. Methods and resultsA tissue microarray cohort comprising 940 tumour samples, of which 502 were metastatic lesions, representing tumours from 18 different organs and four non-localized cancer types, was analysed using immunohistochemistry with 27 well-established antibodies used in clinical differential diagnostics. Few antibodies, e.g. prostate-specific antigen and thyroglobulin, showed a cancer type-related sensitivity and specificity of more than 95%. A majority of the antibodies showed a low degree of sensitivity and specificity for defined cancer types. Combinations of antibodies provided limited added value for differential diagnostics of cancer types. ConclusionsThe results from analysing 27 diagnostic antibodies on consecutive sections of 940 defined tumours provide a unique repository of data that can empower a more optimal use of clinical immunohistochemistry. Our results highlight the benefit of immunohistochemistry and the unmet need for novel markers to improve differential diagnostics of cancer.
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Bergman, JuliaUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)julbe256
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Djureinovic, DijanaUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)dijdj435
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Edqvist, Per-HenrikUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)peedq227
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Maindad, Vikas
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Bharambe, Bhavana M.
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Khan, Wasif Ali Z. A.
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Navani, Sanjay
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Elebro, JacobLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-jce
(author)
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Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji
(author)
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Hellberg, Dan,1953-Uppsala universitet,Centrum för klinisk forskning Dalarna,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa(Swepub:uu)dahel227
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Uhlén, MathiasKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dulvmw
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Micke, PatrickUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)patmi676
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Pontén, FredrikUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)fredpont
(author)
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Uppsala universitetMolekylär och morfologisk patologi
(creator_code:org_t)
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In:Histopathology: Wiley64:2, s. 293-3050309-01671365-2559
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Gremel, Gabriela
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Bergman, Julia
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Djureinovic, Dij ...
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Edqvist, Per-Hen ...
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Maindad, Vikas
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Bharambe, Bhavan ...
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Khan, Wasif Ali ...
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Navani, Sanjay
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Elebro, Jacob
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Jirström, Karin
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Uhlén, Mathias
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Micke, Patrick
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Pontén, Fredrik
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Histopathology
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