Search: onr:"swepub:oai:DiVA.org:uu-216054" > A systematic analys...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05706naa a2200697 4500 | |
001 | oai:DiVA.org:uu-216054 | |
003 | SwePub | |
008 | 140117s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:c22c0aa2-8c37-45ee-a995-5a8388bcff0d | |
009 | oai:DiVA.org:kth-140127 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2160542 URI |
024 | 7 | a https://doi.org/10.1111/his.122552 DOI |
024 | 7 | a https://lup.lub.lu.se/record/42618932 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1401272 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gremel, Gabrielau Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)gabgr787 |
245 | 1 0 | a A systematic analysis of commonly used antibodies in cancer diagnostics |
264 | c 2013-11-05 | |
264 | 1 | b Wiley,c 2014 |
338 | a print2 rdacarrier | |
500 | a De två (2) första författarna delar förstaförfattarskapet. | |
500 | a QC 20140122 | |
520 | a AimsImmunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic power of antibodies used frequently for clinical differential diagnostics. Methods and resultsA tissue microarray cohort comprising 940 tumour samples, of which 502 were metastatic lesions, representing tumours from 18 different organs and four non-localized cancer types, was analysed using immunohistochemistry with 27 well-established antibodies used in clinical differential diagnostics. Few antibodies, e.g. prostate-specific antigen and thyroglobulin, showed a cancer type-related sensitivity and specificity of more than 95%. A majority of the antibodies showed a low degree of sensitivity and specificity for defined cancer types. Combinations of antibodies provided limited added value for differential diagnostics of cancer types. ConclusionsThe results from analysing 27 diagnostic antibodies on consecutive sections of 940 defined tumours provide a unique repository of data that can empower a more optimal use of clinical immunohistochemistry. Our results highlight the benefit of immunohistochemistry and the unmet need for novel markers to improve differential diagnostics of cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
653 | a biological tumour markers | |
653 | a differential diagnosis | |
653 | a immunohistochemistry | |
653 | a surgical pathology | |
653 | a tissue microarray analysis | |
653 | a biological tumour markers | |
653 | a differential diagnosis | |
653 | a immunohistochemistry | |
653 | a surgical pathology | |
653 | a tissue microarray analysis | |
700 | 1 | a Bergman, Juliau Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)julbe256 |
700 | 1 | a Djureinovic, Dijanau Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)dijdj435 |
700 | 1 | a Edqvist, Per-Henriku Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)peedq227 |
700 | 1 | a Maindad, Vikas4 aut |
700 | 1 | a Bharambe, Bhavana M.4 aut |
700 | 1 | a Khan, Wasif Ali Z. A.4 aut |
700 | 1 | a Navani, Sanjay4 aut |
700 | 1 | a Elebro, Jacobu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-jce |
700 | 1 | a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-kji |
700 | 1 | a Hellberg, Dan,d 1953-u Uppsala universitet,Centrum för klinisk forskning Dalarna,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa4 aut0 (Swepub:uu)dahel227 |
700 | 1 | a Uhlén, Mathiasu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dulvmw |
700 | 1 | a Micke, Patricku Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)patmi676 |
700 | 1 | a Pontén, Fredriku Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)fredpont |
710 | 2 | a Uppsala universitetb Molekylär och morfologisk patologi4 org |
773 | 0 | t Histopathologyd : Wileyg 64:2, s. 293-305q 64:2<293-305x 0309-0167x 1365-2559 |
856 | 4 | u http://dx.doi.org/10.1111/his.12255y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216054 |
856 | 4 8 | u https://doi.org/10.1111/his.12255 |
856 | 4 8 | u https://lup.lub.lu.se/record/4261893 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-140127 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Copy and save the link in order to return to this view