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A genome-wide assoc...
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
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Speedy, Helen E. (author)
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Di Bernardo, Maria Chiara (author)
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Sava, Georgina P. (author)
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Dyer, Martin J. S. (author)
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Holroyd, Amy (author)
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Wang, Yufei (author)
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Sunter, Nicola J. (author)
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- Mansouri, Larry (author)
- Uppsala universitet,Hematologi och immunologi
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Smedby, Karin E. (author)
- Karolinska Institutet
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- Roos, Göran (author)
- Umeå universitet,Patologi
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Jayne, Sandrine (author)
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Majid, Aneela (author)
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Dearden, Claire (author)
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Hall, Andrew G. (author)
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Mainou-Fowler, Tryfonia (author)
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Jackson, Graham H. (author)
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Summerfield, Geoffrey (author)
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Harris, Robert J. (author)
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- Rosenquist, Richard (author)
- Uppsala universitet,Hematologi och immunologi
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Allsup, David J. (author)
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Bailey, James R. (author)
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Pratt, Guy (author)
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Pepper, Chris (author)
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Fegan, Chris (author)
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- Rosenquist, Richard (author)
- Uppsala universitet,Hematologi och immunologi
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Catovsky, Daniel (author)
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Allan, James M. (author)
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Houlston, Richard S. (author)
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(creator_code:org_t)
- 2013-12-01
- 2014
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46:1, s. 56-
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Abstract
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- Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 x 10(-9)), 4q26 (rs6858698, P = 3.07 x 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 x 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 x 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 x 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 x 10(-10)) and 8q22.3 (rs2511714, P = 2.90 x 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
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- By the author/editor
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Speedy, Helen E.
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Di Bernardo, Mar ...
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Sava, Georgina P ...
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Dyer, Martin J. ...
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Holroyd, Amy
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Wang, Yufei
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show more...
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Sunter, Nicola J ...
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Mansouri, Larry
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Juliusson, Gunna ...
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Smedby, Karin E.
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Roos, Göran
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Jayne, Sandrine
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Majid, Aneela
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Dearden, Claire
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Hall, Andrew G.
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Mainou-Fowler, T ...
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Jackson, Graham ...
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Summerfield, Geo ...
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Harris, Robert J ...
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Rosenquist, Rich ...
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Allsup, David J.
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Bailey, James R.
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Pratt, Guy
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Pepper, Chris
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Fegan, Chris
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Catovsky, Daniel
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Allan, James M.
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Houlston, Richar ...
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet
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Umeå University