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Effects of prescrib...
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Wändell, PerKarolinska Institutet
(author)
Effects of prescribed antithrombotics and other cardiovascular pharmacotherapies on all-cause mortality in patients with diabetes and atrial fibrillation - a cohort study from Sweden using propensity score analyses
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-01-07
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Springer Science and Business Media LLC,2014
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-218551
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-218551URI
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https://doi.org/10.1186/1758-5996-6-2DOI
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https://lup.lub.lu.se/record/4319582URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128065881URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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AimsTo study mortality rates among patients with diabetes and concomitant atrial fibrillation (AF), prescribed different cardiovascular drugs in primary health care.MethodsStudy population consisted of men (n = 1319) and women (n = 1094) aged = >= 45 years from a database including 75 primary care centres in Sweden. Cox regression analysis, with hazard ratios (HRs), 95% confidence interval (95% CIs) and mortality (years to death) as outcome, and Laplace regression, with difference in time to first 10% mortality (with 95% CI), were performed. Independent variables were prescribed cardiovascular drugs. Regression models were adjusted for a propensity score calculated separately for each prescribed drug class (comprising age, cardiovascular co-morbidities, education, marital status and pharmacotherapy).ResultsOverall mortality was lower in the whole sample for anticoagulants vs no treatment (HR 0.45; 95% CI 0.26-0.77); and among patients < 80 years for anticoagulants vs. antiplatelets (HR 0.44; 95% CI 0.25-0.78); while among individuals aged >= 80 years, antiplatelets (HR 0.47; 95% CI 0.26-0.87) and anticoagulants (HR 0.49; 95% CI 0.24-1.00) vs. no treatment were equally effective. Statins were associated with lower mortality among those < 80 years (HR 0.45; 95% CI 0.29-0.71). Laplace regression models in the whole sample, with years to first 10% of total mortality as outcome, were significant for: among patients < 80 years anticoagulants vs. no treatment 2.70 years (95% CI 0.04-5.37), anticoagulants vs. antiplatelets 2.31 years (95% CI 0.84-3.79), and those >= 80 antiplatelets vs. no treatment 1.78 years (95% CI 1.04-2.52).ConclusionsOur findings suggest that antiplatelets could exert a beneficial effect among those above 80 years.
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Carlsson, Axel C.Karolinska Institutet,Uppsala universitet,Geriatrik(Swepub:uu)axeca883
(author)
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Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-jsu
(author)
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Johansson, Sven-ErikLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-skj
(author)
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Bottai, MatteoKarolinska Institutet
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Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Allmänmedicin och klinisk epidemiologi,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Family Medicine and Clinical Epidemiology(Swepub:lu)med-ksq
(author)
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Karolinska InstitutetGeriatrik
(creator_code:org_t)
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In:Diabetology & Metabolic Syndrome: Springer Science and Business Media LLC6, s. 2-1758-5996
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