Search: onr:"swepub:oai:DiVA.org:uu-219190" >
The association of ...
The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin
-
Newson, R. B. (author)
-
Jones, M. (author)
-
- Forsberg, Bertil (author)
- Umeå universitet,Yrkes- och miljömedicin,Arcum
-
show more...
-
- Janson, Christer (author)
- Uppsala universitet,Lungmedicin och allergologi
-
- Bossios, Apostolos, 1969 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
-
- Dahlen, S. -E (author)
- Karolinska Institutet
-
Toskala, E. M. (author)
-
Al-Kalemji, A. (author)
-
Kowalski, M. L. (author)
-
Rymarczyk, B. (author)
-
Salagean, E. M. (author)
-
van Drunen, C. M. (author)
-
- Bachert, C. (author)
- Karolinska Institutet
-
Wehrend, T. (author)
-
Kraemer, U. (author)
-
Mota-Pinto, A. (author)
-
Burney, P. (author)
-
Leynaert, B. (author)
-
Jarvis, D. (author)
-
show less...
-
(creator_code:org_t)
- 2014-01-22
- 2014
- English.
-
In: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 44:2, s. 250-260
- Related links:
-
https://estudogeral....
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://gup.ub.gu.se...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BackgroundCross-sectional and longitudinal reports show that obese adults have more asthma than non-obese adults. A proposed mechanism is via effects of adipokines (leptin and adiponectin) on the immune system. ObjectiveWe wished to measure the associations of asthma and other atopic diseases with serum adipokine levels and to find whether the associations with asthma were strong enough to rule out the possibility that they are secondary to the association of fatness measures with asthma. MethodsThe Global Asthma and Allergy Network of Excellence (GA(2)LEN) clinical follow-up survey is a clinical survey, embedded in a larger multi-centre cross-sectional postal survey, involving, with a case/control design, enrichment of the sample with subjects with asthma and chronic rhinosinusitis (CRS). We recorded serum leptin or adiponectin in 845 men and 1110 women in 15 centres and also anthropometric measures of fatness including body mass index and waist/hip ratio, current asthma, and specific skin prick and IgE sensitisation. We used inverse sampling-probability-weighted rank and regression statistics to measure population associations of disease outcomes with adipokines in males and females, adjusting for confounders (area, age, smoking history, and number of elder siblings) and also mutually adjusting associations with adipokines and fatness measures. ResultsOne thousand nine hundred and fifty-five subjects aged 16-77years had information on leptin or adiponectin levels. Leptin and leptin/adiponectin ratio were positively associated with the level of asthma, especially in females (Somers' D of leptin by asthma score, 0.20; 95% CI, 0.08-0.30; P=0.00079). These associations were attenuated after adjusting for confounders and became non-significant after additionally adjusting for fatness measures and multiple comparisons. Conclusions and Clinical RelevanceAsthma levels are positively associated with serum leptin. However, we cannot rule out the possibility that this association is secondary to associations of both with fatness measures.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- adiponectin
- asthma
- IgE sensitivity
- leptin
- nasal allergy
- obesity
- skin prick sensitivity
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Newson, R. B.
-
Jones, M.
-
Forsberg, Bertil
-
Janson, Christer
-
Bossios, Apostol ...
-
Dahlen, S. -E
-
show more...
-
Toskala, E. M.
-
Al-Kalemji, A.
-
Kowalski, M. L.
-
Rymarczyk, B.
-
Salagean, E. M.
-
van Drunen, C. M ...
-
Bachert, C.
-
Wehrend, T.
-
Kraemer, U.
-
Mota-Pinto, A.
-
Burney, P.
-
Leynaert, B.
-
Jarvis, D.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Occupational Hea ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Respiratory Medi ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Physiology
- Articles in the publication
-
Clinical and Exp ...
- By the university
-
Uppsala University
-
Umeå University
-
University of Gothenburg
-
Karolinska Institutet