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Prasugrel achieves ...
Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease
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Jernberg, Tomas (author)
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Payne, Christopher D. (author)
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Winters, Kenneth J. (author)
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Darstein, Christelle (author)
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Brandt, John T. (author)
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Jakubowski, Joseph A. (author)
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Naganuma, Hideo (author)
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- Siegbahn, Agneta, 1947- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,UCR
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(creator_code:org_t)
- 2006-04-18
- 2006
- English.
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In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 27:10, s. 1166-1173
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http://www.ncbi.nlm....
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- AIMS: This study was designed to compare the degree of inhibition of platelet aggregation (IPA) of prasugrel with that of clopidogrel in stable aspirin-treated patients with coronary artery disease (CAD). METHODS AND RESULTS: Subjects (n=101) were randomly assigned to the following loading dose (LD) (day 1)/maintenance dose (MD) (days 2-28) combinations: prasugrel, 40 mg/5 mg; 40 mg/7.5 mg; 60 mg/10 mg; 60 mg/15 mg; or clopidogrel, 300 mg/75 mg. Turbidometric platelet aggregation was measured at multiple timepoints during the study. At 4 h after dosing, with 20 microM ADP, both prasugrel LDs achieved significantly higher mean IPA levels (60.6% and 68.4 vs. 30.0%, respectively; all P<0.0001) and lower percentage (3 vs. 52%, P<0.0001) of pharmacodynamic non-responders (defined as IPA <20%) than clopidogrel. Prasugrel 10 and 15 mg MDs achieved consistently higher mean IPA than clopidogrel 75 mg at day 28 (all P<0.0001). At pre-MD on day 28, there were no non-responders in the 10 and 15 mg prasugrel group, compared with 45% in the clopidogrel group (P=0.0007). CONCLUSION: In this population, prasugrel (40-60 mg LD and 10-15 mg MD) achieves greater IPA and a lower proportion of pharmacodynamic non-responders compared with the approved clopidogrel dosing.
Keyword
- MEDICINE
- MEDICIN
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- art (subject category)
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Jernberg, Tomas
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Payne, Christoph ...
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Winters, Kenneth ...
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Darstein, Christ ...
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Brandt, John T.
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Jakubowski, Jose ...
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show more...
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Naganuma, Hideo
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Siegbahn, Agneta ...
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Wallentin, Lars, ...
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- Articles in the publication
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European Heart J ...
- By the university
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Uppsala University