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Dabigatran Versus W...
Dabigatran Versus Warfarin Effects on Ischemic and Hemorrhagic Strokes and Bleeding in Asians and Non-Asians With Atrial Fibrillation
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Hori, Masatsugu (author)
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Connolly, Stuart J. (author)
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Zhu, Jun (author)
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Liu, Li Sheng (author)
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Lau, Chu-Pak (author)
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Pais, Prem (author)
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Xavier, Denis (author)
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Kim, Sung Soon (author)
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Omar, Razali (author)
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Dans, Antonio L. (author)
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Tan, Ru San (author)
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Chen, Jyh-Hong (author)
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Tanomsup, Supachai (author)
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Watanabe, Mitsunori (author)
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Koyanagi, Masahide (author)
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Ezekowitz, Michael D. (author)
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Reilly, Paul A. (author)
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- Wallentin, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
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Yusuf, Salim (author)
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Stroke. - 0039-2499 .- 1524-4628. ; 44:7, s. 1891-
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background and Purpose-Intracranial hemorrhage rates are higher in Asians than non-Asians, especially in patients receiving warfarin. This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries. Methods-There were 2782 patients (15%) from 10 Asian countries and 15 331 patients from 34 non-Asian countries. A Cox regression model, with terms for treatment, region, and their interaction was used. Results-Rates of stroke or systemic embolism in Asians were 3.06% per year on warfarin, 2.50% per year on DE 110 mg BID (DE 110), and 1.39% per year on DE 150 mg BID (DE 150); in non-Asians, the rates were 1.48%, 1.37%, and 1.06% per year with no significant treatment-by-region interactions. Hemorrhagic stroke on warfarin occurred more often in Asians than non-Asians (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.3-4.7; P=0.007), with significant reductions for DE compared with warfarin in both Asian (DE 110 versus warfarin HR, 0.15; 95% CI, 0.03-0.66 and DE 150 versus warfarin HR, 0.22; 95% CI, 0.06-0.77) and non-Asian (DE 110 versus warfarin HR, 0.37; 95% CI, 0.19-0.72 and DE 150 versus warfarin HR, 0.28; 95% CI, 0.13-0.58) patients. Major bleeding rates in Asians were significantly lower on DE (both doses) than warfarin (warfarin 3.82% per year, DE 110 2.22% per year, and DE 150 2.17% per year). Conclusions-Hemorrhagic stroke rates were higher on warfarin in Asians versus non-Asians, despite similar blood pressure, younger age, and lower international normalized ratio values. Hemorrhagic strokes were significantly reduced by DE in both Asians and non-Asians. DE benefits were consistent across Asian and non-Asian subgroups.
Keyword
- Asia
- atrial fibrillation
- bleeding
- dabigatran
- intracranial hemorrhage
- RE-LY
- warfarin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Stroke
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To the university's database
- By the author/editor
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Hori, Masatsugu
-
Connolly, Stuart ...
-
Zhu, Jun
-
Liu, Li Sheng
-
Lau, Chu-Pak
-
Pais, Prem
-
show more...
-
Xavier, Denis
-
Kim, Sung Soon
-
Omar, Razali
-
Dans, Antonio L.
-
Tan, Ru San
-
Chen, Jyh-Hong
-
Tanomsup, Supach ...
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Watanabe, Mitsun ...
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Koyanagi, Masahi ...
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Ezekowitz, Micha ...
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Reilly, Paul A.
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Wallentin, Lars
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Yusuf, Salim
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show less...
- Articles in the publication
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Stroke
- By the university
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Uppsala University