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  • Hori, Masatsugu (author)

Dabigatran Versus Warfarin Effects on Ischemic and Hemorrhagic Strokes and Bleeding in Asians and Non-Asians With Atrial Fibrillation

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-219883
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219883URI
  • https://doi.org/10.1161/STROKEAHA.113.000990DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background and Purpose-Intracranial hemorrhage rates are higher in Asians than non-Asians, especially in patients receiving warfarin. This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries. Methods-There were 2782 patients (15%) from 10 Asian countries and 15 331 patients from 34 non-Asian countries. A Cox regression model, with terms for treatment, region, and their interaction was used. Results-Rates of stroke or systemic embolism in Asians were 3.06% per year on warfarin, 2.50% per year on DE 110 mg BID (DE 110), and 1.39% per year on DE 150 mg BID (DE 150); in non-Asians, the rates were 1.48%, 1.37%, and 1.06% per year with no significant treatment-by-region interactions. Hemorrhagic stroke on warfarin occurred more often in Asians than non-Asians (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.3-4.7; P=0.007), with significant reductions for DE compared with warfarin in both Asian (DE 110 versus warfarin HR, 0.15; 95% CI, 0.03-0.66 and DE 150 versus warfarin HR, 0.22; 95% CI, 0.06-0.77) and non-Asian (DE 110 versus warfarin HR, 0.37; 95% CI, 0.19-0.72 and DE 150 versus warfarin HR, 0.28; 95% CI, 0.13-0.58) patients. Major bleeding rates in Asians were significantly lower on DE (both doses) than warfarin (warfarin 3.82% per year, DE 110 2.22% per year, and DE 150 2.17% per year). Conclusions-Hemorrhagic stroke rates were higher on warfarin in Asians versus non-Asians, despite similar blood pressure, younger age, and lower international normalized ratio values. Hemorrhagic strokes were significantly reduced by DE in both Asians and non-Asians. DE benefits were consistent across Asian and non-Asian subgroups.

Subject headings and genre

  • Asia
  • atrial fibrillation
  • bleeding
  • dabigatran
  • intracranial hemorrhage
  • RE-LY
  • warfarin

Added entries (persons, corporate bodies, meetings, titles ...)

  • Connolly, Stuart J. (author)
  • Zhu, Jun (author)
  • Liu, Li Sheng (author)
  • Lau, Chu-Pak (author)
  • Pais, Prem (author)
  • Xavier, Denis (author)
  • Kim, Sung Soon (author)
  • Omar, Razali (author)
  • Dans, Antonio L. (author)
  • Tan, Ru San (author)
  • Chen, Jyh-Hong (author)
  • Tanomsup, Supachai (author)
  • Watanabe, Mitsunori (author)
  • Koyanagi, Masahide (author)
  • Ezekowitz, Michael D. (author)
  • Reilly, Paul A. (author)
  • Wallentin, LarsUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper(Swepub:uu)larswall (author)
  • Yusuf, Salim (author)
  • Uppsala universitetUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

Related titles

  • In:Stroke44:7, s. 1891-+0039-24991524-4628

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