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Dabigatran Versus W...
Dabigatran Versus Warfarin Effects on Ischemic and Hemorrhagic Strokes and Bleeding in Asians and Non-Asians With Atrial Fibrillation
- Article/chapterEnglish2013
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-219883
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219883URI
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https://doi.org/10.1161/STROKEAHA.113.000990DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background and Purpose-Intracranial hemorrhage rates are higher in Asians than non-Asians, especially in patients receiving warfarin. This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries. Methods-There were 2782 patients (15%) from 10 Asian countries and 15 331 patients from 34 non-Asian countries. A Cox regression model, with terms for treatment, region, and their interaction was used. Results-Rates of stroke or systemic embolism in Asians were 3.06% per year on warfarin, 2.50% per year on DE 110 mg BID (DE 110), and 1.39% per year on DE 150 mg BID (DE 150); in non-Asians, the rates were 1.48%, 1.37%, and 1.06% per year with no significant treatment-by-region interactions. Hemorrhagic stroke on warfarin occurred more often in Asians than non-Asians (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.3-4.7; P=0.007), with significant reductions for DE compared with warfarin in both Asian (DE 110 versus warfarin HR, 0.15; 95% CI, 0.03-0.66 and DE 150 versus warfarin HR, 0.22; 95% CI, 0.06-0.77) and non-Asian (DE 110 versus warfarin HR, 0.37; 95% CI, 0.19-0.72 and DE 150 versus warfarin HR, 0.28; 95% CI, 0.13-0.58) patients. Major bleeding rates in Asians were significantly lower on DE (both doses) than warfarin (warfarin 3.82% per year, DE 110 2.22% per year, and DE 150 2.17% per year). Conclusions-Hemorrhagic stroke rates were higher on warfarin in Asians versus non-Asians, despite similar blood pressure, younger age, and lower international normalized ratio values. Hemorrhagic strokes were significantly reduced by DE in both Asians and non-Asians. DE benefits were consistent across Asian and non-Asian subgroups.
Subject headings and genre
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Asia
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atrial fibrillation
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bleeding
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dabigatran
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intracranial hemorrhage
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RE-LY
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warfarin
Added entries (persons, corporate bodies, meetings, titles ...)
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Connolly, Stuart J.
(author)
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Zhu, Jun
(author)
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Liu, Li Sheng
(author)
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Lau, Chu-Pak
(author)
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Pais, Prem
(author)
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Xavier, Denis
(author)
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Kim, Sung Soon
(author)
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Omar, Razali
(author)
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Dans, Antonio L.
(author)
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Tan, Ru San
(author)
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Chen, Jyh-Hong
(author)
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Tanomsup, Supachai
(author)
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Watanabe, Mitsunori
(author)
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Koyanagi, Masahide
(author)
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Ezekowitz, Michael D.
(author)
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Reilly, Paul A.
(author)
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Wallentin, LarsUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper(Swepub:uu)larswall
(author)
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Yusuf, Salim
(author)
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Uppsala universitetUppsala kliniska forskningscentrum (UCR)
(creator_code:org_t)
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In:Stroke44:7, s. 1891-+0039-24991524-4628
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Hori, Masatsugu
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Connolly, Stuart ...
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Zhu, Jun
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Liu, Li Sheng
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Lau, Chu-Pak
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Pais, Prem
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Xavier, Denis
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Kim, Sung Soon
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Omar, Razali
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Dans, Antonio L.
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Tan, Ru San
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Chen, Jyh-Hong
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Tanomsup, Supach ...
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Watanabe, Mitsun ...
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Koyanagi, Masahi ...
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Ezekowitz, Micha ...
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Reilly, Paul A.
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Wallentin, Lars
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Yusuf, Salim
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Stroke
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Uppsala University