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Interobserver Varia...
Interobserver Variability of Histopathological Prognostic Parameters in Cutaneous Malignant Melanoma : Impact on Patient Management
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- Eriksson, Hanna (author)
- Karolinska Institutet
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- Frohm-Nilsson, Margareta (author)
- Karolinska Institutet
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Hedblad, Mari-Anne (author)
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Hellborg, Henrik (author)
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- Kanter-Lewensohn, Lena (author)
- Karolinska Institutet
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Krawiec, Kamilla (author)
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- Lundh Rozell, Barbro (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Mansson-Brahme, Eva (author)
- Karolinska Institutet
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- Hansson, Johan (author)
- Karolinska Institutet
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(creator_code:org_t)
- Medical Journals Sweden AB, 2013
- 2013
- English.
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In: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 93:4, s. 411-416
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Abstract
Subject headings
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- Clinical management of primary cutaneous melanomas is based on histopathological staging of the tumour. The aim of this study was to investigate, in a non-selected population in clinical practice, the agreement rate between general pathologists and pathologists experienced in melanoma in terms of the evaluation of histopathological prognostic parameters in cutaneous malignant melanomas, and to what extent the putative variability affected clinical management. A total of 234 cases of invasive cutaneous malignant melanoma were included in the study from the Stockholm-Gotland Healthcare Region in Sweden. Overall interobserver variability between a general pathologist and an expert review was 68.8-84.8%. Approximately 15.5% of melanomas <= 1 mm were re-classified either as melanoma in situ or melanomas >1 mm after review. In conclusion, review by a pathologist experienced in melanoma resulted in a change in recommendations about surgical excision margins and/or sentinel node biopsy in subgroups of Ti melanomas.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- melanoma
- pathology
- prognosis
- interobserver
- variability
- treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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