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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03348naa a2200373 4500 | |
| 001 | oai:DiVA.org:uu-220769 | |
| 003 | SwePub | |
| 008 | 140320s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2207692 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jpba.2014.05.0012 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Rydevik, Axelu Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi4 aut0 (Swepub:uu)axery729 |
| 245 | 1 0 | a Isolation and characterization of a beta-glucuronide of hydroxylated SARM S1 produced using a combination of biotransformation and chemical oxidation |
| 264 | 1 | b Elsevier BV,c 2014 |
| 338 | a print2 rdacarrier | |
| 520 | a In this study, using mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, it has been confirmed that biotransformation with the fungus Cunninghamella elegans combined with chemical oxidation with the free radical tetramethylpiperidinyl-1-oxy (TEMPO) can produce drug glucuronides of beta-configuration. Glucuronic acid conjugates are a common type of metabolites formed by the human body. The detection of such conjugates in doping control and other kinds of forensic analysis would be beneficial owing to a decrease in analysis time as hydrolysis can be omitted. However the commercial availability of reference standards for drug glucuronides is poor. The selective androgen receptor modulator (SARM) SARM Si was incubated with the fungus C elegans. The sample was treated with the free radical TEMPO oxidizing agent and was thereafter purified by SPE. A glucuronic acid conjugate was isolated using a fraction collector connected to an ultra high performance liquid chromatographic (UHPLC) system. The isolated compound was characterized by NMR spectroscopy and mass spectrometry and its structure was confirmed as a glucuronic acid beta-conjugate of hydroxylated SARM Si bearing the glucuronide moiety on carbon C-10. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng |
| 653 | a Analytical Pharmaceutical Chemistry | |
| 653 | a Analytisk farmaceutisk kemi | |
| 700 | 1 | a Lagojda, Andreasu Bayer CropScience AG4 aut |
| 700 | 1 | a Thevis, Mariou Institute of Biochemistry and Center for Preventive Doping Research, German Sport University, Cologne4 aut |
| 700 | 1 | a Bondesson, Ulfu Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi4 aut0 (Swepub:uu)ulfbonde |
| 700 | 1 | a Hedeland, Mikaelu Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi4 aut0 (Swepub:uu)mikahede |
| 710 | 2 | a Uppsala universitetb Avdelningen för analytisk farmaceutisk kemi4 org |
| 773 | 0 | t Journal of Pharmaceutical and Biomedical Analysisd : Elsevier BVg 98, s. 36-39q 98<36-39x 0731-7085x 1873-264X |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220769 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jpba.2014.05.001 |
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