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Higher World Health...
Higher World Health Organization grades of follicular lymphoma correlate with better outcome in two Nordic Lymphoma Group trials of rituximab without chemotherapy
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- Wahlin, Bjorn Engelbrekt (author)
- Karolinska Institutet
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- Sundström, Christer (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Sander, Birgitta (author)
- Karolinska Institutet
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- Christensson, Birger (author)
- Karolinska Institutet
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Jeppsson-Ahlberg, Asa (author)
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- Hjalmarsson, Eric (author)
- Karolinska Institutet
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Holte, Harald (author)
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Ostenstad, Bjorn (author)
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Brown, Peter D. (author)
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Smeland, Erlend Bremertun (author)
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- Kimby, Eva (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2013-06-14
- 2014
- English.
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In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 55:2, s. 288-295
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- A common treatment for follicular lymphoma is rituximab monotherapy. To identify patients for whom this regimen is adequate as first-line therapy, we applied the World Health Organization (WHO) classification for grading follicular lymphoma in a prospective central pathology review of the biopsies of previously untreated patients in two randomized trials of rituximab without chemotherapy. In the first trial (n(1) = 53), higher WHO grades correlated with longer time to next treatment, independently of clinical prognostic factors (p = 0.030); the finding was replicated in the second trial (n(2) = 221; p = 0.019). Higher grades were associated with better treatment responses (p = 0.018). Furthermore, also grades externally confirmed by independent local pathologists correlated with time to next treatment (p = 0.048). Flow cytometry in a separate patient series showed that the intensity of CD20 increased with the malignant cell size (p < 0.00005). In conclusion, WHO grade 1 follicular lymphoma correlates with inferior outcome after rituximab monotherapy. WHO grading might provide a clinically useful tool for personalized therapy.
Keyword
- Follicular lymphoma
- WHO
- grades
- rituximab
- CD20
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wahlin, Bjorn En ...
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Sundström, Chris ...
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Sander, Birgitta
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Christensson, Bi ...
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Jeppsson-Ahlberg ...
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Hjalmarsson, Eri ...
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show more...
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Holte, Harald
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Ostenstad, Bjorn
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Brown, Peter D.
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Smeland, Erlend ...
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Kimby, Eva
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show less...
- Articles in the publication
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Leukemia and Lym ...
- By the university
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Uppsala University
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Karolinska Institutet