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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09099naa a2202461 4500 | |
| 001 | oai:DiVA.org:uu-223048 | |
| 003 | SwePub | |
| 008 | 140416s2012 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:124171017 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2230482 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.10512 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1241710172 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Stolk, Lisette4 aut |
| 245 | 1 0 | a Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways |
| 264 | c 2012-01-22 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2012 |
| 338 | a print2 rdacarrier | |
| 520 | a To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause. | |
| 700 | 1 | a Perry, John R B4 aut |
| 700 | 1 | a Chasman, Daniel I4 aut |
| 700 | 1 | a He, Chunyan4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a Sulem, Patrick4 aut |
| 700 | 1 | a Barbalic, Maja4 aut |
| 700 | 1 | a Broer, Linda4 aut |
| 700 | 1 | a Byrne, Enda M4 aut |
| 700 | 1 | a Ernst, Florian4 aut |
| 700 | 1 | a Esko, Tõnu4 aut |
| 700 | 1 | a Franceschini, Nora4 aut |
| 700 | 1 | a Gudbjartsson, Daniel F4 aut |
| 700 | 1 | a Hottenga, Jouke-Jan4 aut |
| 700 | 1 | a Kraft, Peteru Karolinska Institutet4 aut |
| 700 | 1 | a McArdle, Patrick F4 aut |
| 700 | 1 | a Porcu, Eleonora4 aut |
| 700 | 1 | a Shin, So-Youn4 aut |
| 700 | 1 | a Smith, Albert V4 aut |
| 700 | 1 | a van Wingerden, Sophie4 aut |
| 700 | 1 | a Zhai, Guangju4 aut |
| 700 | 1 | a Zhuang, Wei V4 aut |
| 700 | 1 | a Albrecht, Eva4 aut |
| 700 | 1 | a Alizadeh, Behrooz Z4 aut |
| 700 | 1 | a Aspelund, Thor4 aut |
| 700 | 1 | a Bandinelli, Stefania4 aut |
| 700 | 1 | a Lauc, Lovorka Barac4 aut |
| 700 | 1 | a Beckmann, Jacques S4 aut |
| 700 | 1 | a Boban, Mladen4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Broekmans, Frank J4 aut |
| 700 | 1 | a Burri, Andrea4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Chanock, Stephen J4 aut |
| 700 | 1 | a Chen, Constance4 aut |
| 700 | 1 | a Cornelis, Marilyn C4 aut |
| 700 | 1 | a Corre, Tanguy4 aut |
| 700 | 1 | a Coviello, Andrea D4 aut |
| 700 | 1 | a d'Adamo, Pio4 aut |
| 700 | 1 | a Davies, Gail4 aut |
| 700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
| 700 | 1 | a de Geus, Eco J C4 aut |
| 700 | 1 | a Deary, Ian J4 aut |
| 700 | 1 | a Dedoussis, George V Z4 aut |
| 700 | 1 | a Deloukas, Panagiotis4 aut |
| 700 | 1 | a Ebrahim, Shah4 aut |
| 700 | 1 | a Eiriksdottir, Gudny4 aut |
| 700 | 1 | a Emilsson, Valur4 aut |
| 700 | 1 | a Eriksson, Johan G4 aut |
| 700 | 1 | a Fauser, Bart C J M4 aut |
| 700 | 1 | a Ferreli, Liana4 aut |
| 700 | 1 | a Ferrucci, Luigi4 aut |
| 700 | 1 | a Fischer, Krista4 aut |
| 700 | 1 | a Folsom, Aaron R4 aut |
| 700 | 1 | a Garcia, Melissa E4 aut |
| 700 | 1 | a Gasparini, Paolo4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Glazer, Nicole4 aut |
| 700 | 1 | a Grobbee, Diederick E4 aut |
| 700 | 1 | a Hall, Peru Karolinska Institutet4 aut |
| 700 | 1 | a Haller, Toomas4 aut |
| 700 | 1 | a Hankinson, Susan E4 aut |
| 700 | 1 | a Hass, Merli4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Heath, Andrew C4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Ingelsson, Erik,d 1975-u Karolinska Institutet4 aut0 (Swepub:uu)ering425 |
| 700 | 1 | a Janssens, A Cecile J W4 aut |
| 700 | 1 | a Johnson, Andrew D4 aut |
| 700 | 1 | a Karasik, David4 aut |
| 700 | 1 | a Kardia, Sharon L R4 aut |
| 700 | 1 | a Keyzer, Jules4 aut |
| 700 | 1 | a Kiel, Douglas P4 aut |
| 700 | 1 | a Kolcic, Ivana4 aut |
| 700 | 1 | a Kutalik, Zoltán4 aut |
| 700 | 1 | a Lahti, Jari4 aut |
| 700 | 1 | a Lai, Sandra4 aut |
| 700 | 1 | a Laisk, Triin4 aut |
| 700 | 1 | a Laven, Joop S E4 aut |
| 700 | 1 | a Lawlor, Debbie A4 aut |
| 700 | 1 | a Liu, Jianjun4 aut |
| 700 | 1 | a Lopez, Lorna M4 aut |
| 700 | 1 | a Louwers, Yvonne V4 aut |
| 700 | 1 | a Magnusson, Patrik K E4 aut |
| 700 | 1 | a Marongiu, Mara4 aut |
| 700 | 1 | a Martin, Nicholas G4 aut |
| 700 | 1 | a Klaric, Irena Martinovic4 aut |
| 700 | 1 | a Masciullo, Corrado4 aut |
| 700 | 1 | a McKnight, Barbara4 aut |
| 700 | 1 | a Medland, Sarah E4 aut |
| 700 | 1 | a Melzer, David4 aut |
| 700 | 1 | a Mooser, Vincent4 aut |
| 700 | 1 | a Navarro, Pau4 aut |
| 700 | 1 | a Newman, Anne B4 aut |
| 700 | 1 | a Nyholt, Dale R4 aut |
| 700 | 1 | a Onland-Moret, N Charlotte4 aut |
| 700 | 1 | a Palotie, Aarno4 aut |
| 700 | 1 | a Paré, Guillaume4 aut |
| 700 | 1 | a Parker, Alex N4 aut |
| 700 | 1 | a Pedersen, Nancy Lu Karolinska Institutet4 aut |
| 700 | 1 | a Peeters, Petra H M4 aut |
| 700 | 1 | a Pistis, Giorgio4 aut |
| 700 | 1 | a Plump, Andrew S4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Pop, Victor J M4 aut |
| 700 | 1 | a Psaty, Bruce M4 aut |
| 700 | 1 | a Räikkönen, Katri4 aut |
| 700 | 1 | a Rehnberg, Emil4 aut |
| 700 | 1 | a Rotter, Jerome I4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Sala, Cinzia4 aut |
| 700 | 1 | a Salumets, Andres4 aut |
| 700 | 1 | a Scuteri, Angelo4 aut |
| 700 | 1 | a Singleton, Andrew4 aut |
| 700 | 1 | a Smith, Jennifer A4 aut |
| 700 | 1 | a Snieder, Harold4 aut |
| 700 | 1 | a Soranzo, Nicole4 aut |
| 700 | 1 | a Stacey, Simon N4 aut |
| 700 | 1 | a Starr, John M4 aut |
| 700 | 1 | a Stathopoulou, Maria G4 aut |
| 700 | 1 | a Stirrups, Kathleen4 aut |
| 700 | 1 | a Stolk, Ronald P4 aut |
| 700 | 1 | a Styrkarsdottir, Unnur4 aut |
| 700 | 1 | a Sun, Yan V4 aut |
| 700 | 1 | a Tenesa, Albert4 aut |
| 700 | 1 | a Thorand, Barbara4 aut |
| 700 | 1 | a Toniolo, Daniela4 aut |
| 700 | 1 | a Tryggvadottir, Laufey4 aut |
| 700 | 1 | a Tsui, Kim4 aut |
| 700 | 1 | a Ulivi, Sheila4 aut |
| 700 | 1 | a van Dam, Rob M4 aut |
| 700 | 1 | a van der Schouw, Yvonne T4 aut |
| 700 | 1 | a van Gils, Carla H4 aut |
| 700 | 1 | a van Nierop, Peter4 aut |
| 700 | 1 | a Vink, Jacqueline M4 aut |
| 700 | 1 | a Visscher, Peter M4 aut |
| 700 | 1 | a Voorhuis, Marlies4 aut |
| 700 | 1 | a Waeber, Gérard4 aut |
| 700 | 1 | a Wallaschofski, Henri4 aut |
| 700 | 1 | a Wichmann, H Erich4 aut |
| 700 | 1 | a Widen, Elisabeth4 aut |
| 700 | 1 | a Wijnands-van Gent, Colette J M4 aut |
| 700 | 1 | a Willemsen, Gonneke4 aut |
| 700 | 1 | a Wilson, James F4 aut |
| 700 | 1 | a Wolffenbuttel, Bruce H R4 aut |
| 700 | 1 | a Wright, Alan F4 aut |
| 700 | 1 | a Yerges-Armstrong, Laura M4 aut |
| 700 | 1 | a Zemunik, Tatijana4 aut |
| 700 | 1 | a Zgaga, Lina4 aut |
| 700 | 1 | a Zillikens, M Carola4 aut |
| 700 | 1 | a Zygmunt, Marek4 aut |
| 700 | 1 | a Study, The Lifelines Cohort4 aut |
| 700 | 1 | a Arnold, Alice M4 aut |
| 700 | 1 | a Boomsma, Dorret I4 aut |
| 700 | 1 | a Buring, Julie E4 aut |
| 700 | 1 | a Crisponi, Laura4 aut |
| 700 | 1 | a Demerath, Ellen W4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Harris, Tamara B4 aut |
| 700 | 1 | a Hu, Frank B4 aut |
| 700 | 1 | a Hunter, David J4 aut |
| 700 | 1 | a Launer, Lenore J4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Montgomery, Grant W4 aut |
| 700 | 1 | a Oostra, Ben A4 aut |
| 700 | 1 | a Ridker, Paul M4 aut |
| 700 | 1 | a Sanna, Serena4 aut |
| 700 | 1 | a Schlessinger, David4 aut |
| 700 | 1 | a Spector, Tim D4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a Streeten, Elizabeth A4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a Uda, Manuela4 aut |
| 700 | 1 | a Uitterlinden, André G4 aut |
| 700 | 1 | a van Duijn, Cornelia M4 aut |
| 700 | 1 | a Völzke, Henry4 aut |
| 700 | 1 | a Murray, Anna4 aut |
| 700 | 1 | a Murabito, Joanne M4 aut |
| 700 | 1 | a Visser, Jenny A4 aut |
| 700 | 1 | a Lunetta, Kathryn L4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 44:3, s. 260-268q 44:3<260-268x 1061-4036x 1546-1718 |
| 856 | 4 | u https://www.pure.ed.ac.uk/ws/files/8324829/Meta_analyses_identify_13_loci_associated_with_age_at_menopause_and_highlight_DNA_repair_and_immune_pathways.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223048 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.1051 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:124171017 |
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