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  • Fransson, MoaUppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab (author)

Intranasal Delivery of CNS-Retargeted Human Mesenchymal Stromal Cells Prolongs Treatment Efficacy of Experimental Autoimmune Encephalomyelitis

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-06-10
  • Wiley,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-223631
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223631URI
  • https://doi.org/10.1111/imm.12275DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De två första författarna delar förstaförfattarskapet.
  • Treatment with mesenchymal stromal cells (MSC) is currently of interest for a number of diseases including multiple sclerosis (MS). MSCs is well known to target inflamed tissues however, in a therapeutic scenery, systemic administration will lead to few cells reaching the brain. We hypothesized that MSCs may target the brain upon intranasal (i.n) administration and persist in CNS tissue if expressing a CNS-targeting receptor. To demonstrate proof of concept, MSCs were genetically engineered to express a myelin oligodendrocyte glycoprotein (MOG)-specific receptor. Engineered MSCs retained their immunosuppressive capacity, infiltrated into the brain upon i.n. cell administration, and were able to significantly reduce disease symptoms of experimental autoimmune encephalomyelitis (EAE). The mice treated with CNS-targeting MSCs were resistant to further EAE induction whereas non-targeted MSC did not give such persistent effects. Histological analysis revealed increased brain restoration in engineered MSC-treated mice. In conclusion, MSCs can be genetically engineered to target the brain and prolong therapeutic efficacy in an EAE model.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Piras, ElenaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)elpir677 (author)
  • Wang, HaoUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab (author)
  • Burman, JoachimUppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab,Neurologi(Swepub:uu)joabu293 (author)
  • Duprez, IdaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab (author)
  • Harris, Robert A (author)
  • Leblanc, Katarina (author)
  • Magnusson, Peetra UUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk immunologi(Swepub:uu)petrmagn (author)
  • Brittebo, EvaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)evabritt (author)
  • Loskog, Angelica S IUppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)angelosk (author)
  • Uppsala universitetKlinisk immunologi (creator_code:org_t)

Related titles

  • In:Immunology: Wiley142:3, s. 431-4410019-28051365-2567

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