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Overfeeding Polyuns...
Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans
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- Rosqvist, Fredrik (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Iggman, David (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Kullberg, Joel (author)
- Uppsala universitet,Enheten för radiologi
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- Cedernaes, Jonathan (author)
- Uppsala universitet,Funktionell farmakologi
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- Johansson, Hans-Erik (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Larsson, Anders (author)
- Uppsala universitet,Biokemisk struktur och funktion
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- Johansson, Lars (author)
- Uppsala universitet,Enheten för radiologi
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- Ahlström, Håkan (author)
- Uppsala universitet,Enheten för radiologi
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- Arner, Peter (author)
- Karolinska Institutet
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- Dahlman, Ingrid (author)
- Karolinska Institutet
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- Risérus, Ulf (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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(creator_code:org_t)
- 2014-06-14
- 2014
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 63:7, s. 2356-2368
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https://diabetes.dia...
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https://urn.kb.se/re...
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Abstract
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- Excess ectopic fat storage is linked to type 2 diabetes. The importance of dietary fat composition for ectopic fat storage in humans is unknown. We investigated liver fat accumulation and body composition during overfeeding saturated (SFA) or polyunsaturated (PUFA) fat. LIPOGAIN was a double-blind, parallel-group, randomized trial. Thirty-nine young and normal-weight individuals were overfed muffins high in SFA (palm oil) or n-6 PUFA (sunflower oil) for 7 weeks. Liver fat, visceral (VAT), subcutaneous abdominal (SAT), and total adipose tissue (TAT), pancreatic fat, and lean tissue was assessed by MRI. Transcriptomics were performed in SAT. Both groups gained similar weight. SFA however markedly increased liver fat compared with PUFA and caused 2-fold larger increase in VAT than PUFA. Conversely, PUFA caused a nearly 3-fold larger increase in lean tissue than SFA. Increase in liver fat directly correlated with changes in plasma SFA and inversely with PUFA. Genes involved in regulating energy dissipation, insulin resistance, body composition and fat cell differentiation in SAT were differentially regulated between diets, and associated with increased PUFA in SAT. In conclusion, overeating SFA promotes hepatic and visceral fat storage whereas excess energy from PUFA may instead promote lean tissue in healthy humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Diabetes
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- By the author/editor
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Rosqvist, Fredri ...
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Iggman, David
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Kullberg, Joel
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Cedernaes, Jonat ...
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Johansson, Hans- ...
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Larsson, Anders
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show more...
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Johansson, Lars
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Ahlström, Håkan
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Arner, Peter
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Dahlman, Ingrid
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Risérus, Ulf
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Uppsala University
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Karolinska Institutet