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Plasma alkylresorci...
Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity : a randomized study
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Magnusdottir, O. K. (author)
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- Landberg, Rikard (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science,Karolinska Institute
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Gunnarsdottir, I. (author)
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- Cloetens, L (author)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Akesson, B (author)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Skåne University Hospital
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- Landin-Olsson, Mona (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Rosqvist, Fredrik (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Iggman, David (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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Schwab, U. (author)
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Herzig, K-H (author)
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Savolainen, M. J. (author)
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Brader, L. (author)
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Hermansen, K. (author)
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Kolehmainen, M. (author)
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Poutanen, K. (author)
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- Uusitupa, Matti (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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Thorsdottir, I. (author)
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- Risérus, Ulf (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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(creator_code:org_t)
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- 2014-02-19
- 2014
- English.
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In: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 0954-3007 .- 1476-5640. ; 68:4, s. 453-458
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND/OBJECTIVES: Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS). SUBJECTS/METHODS: Participants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND + control) regression analyses at 18/24 weeks. RESULTS: ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks. CONCLUSIONS: The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- alkylresorcinols
- insulin sensitivity
- whole grain
- rye
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Magnusdottir, O. ...
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Landberg, Rikard
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Gunnarsdottir, I ...
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Cloetens, L
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Akesson, B
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Landin-Olsson, M ...
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show more...
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Rosqvist, Fredri ...
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Iggman, David
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Schwab, U.
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Herzig, K-H
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Savolainen, M. J ...
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Brader, L.
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Hermansen, K.
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Kolehmainen, M.
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Poutanen, K.
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Uusitupa, Matti
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Thorsdottir, I.
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Risérus, Ulf
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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MEDICAL AND HEAL ...
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and Other Clinical M ...
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences
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Lund University
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Karolinska Institutet