Search: onr:"swepub:oai:DiVA.org:uu-225073" >
N-Aryl Isoleucine D...
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Behrends, MalteUppsala universitet,Avdelningen för organisk farmaceutisk kemi
(author)
N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-03-13
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Wiley,2014
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-225073
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-225073URI
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https://doi.org/10.1002/open.201300040DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A novel series of ligands for the recombinant human AT(2) receptor has been synthesized utilizing a fast and efficient palladium-catalyzed procedure for aminocarbonylation as the key reaction. Molybdenum hexacarbonyl [Mo(CO)(6)] was employed as the carbon monoxide source, and controlled microwave heating was applied. The prepared N-aryl isoleucine derivatives, encompassing a variety of amide groups attached to the aromatic system, exhibit binding affinities at best with K-i values in the low micromolar range versus the recombinant human AT(2) receptor. Some of the new nonpeptidic isoleucine derivatives may serve as starting points for further structural optimization. The presented data emphasize the importance of using human receptors in drug discovery programs.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Wallinder, CharlottaUppsala universitet,Avdelningen för organisk farmaceutisk kemi(Swepub:uu)chwal103
(author)
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Wieckowska, AnnaUppsala universitet,Avdelningen för organisk farmaceutisk kemi
(author)
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Guimond, Marie-Odile
(author)
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Hallberg, AndersUppsala universitet,Avdelningen för organisk farmaceutisk kemi(Swepub:uu)andehall
(author)
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Gallo-Payet, Nicole
(author)
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Larhed, MatsUppsala universitet,Avdelningen för organisk farmaceutisk kemi(Swepub:uu)matslarh
(author)
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Uppsala universitetAvdelningen för organisk farmaceutisk kemi
(creator_code:org_t)
Related titles
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In:ChemistryOpen: Wiley3:2, s. 65-752191-1363
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