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Ovarian carcinoma h...
Ovarian carcinoma histotype determination is highly reproducible, and is improved through the use of immunohistochemistry
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- Koebel, Martin (author)
- Calgary Lab Serv, Canada University of Calgary, Canada
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- Bak, Julia (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Bertelsen, Bjorn I. (author)
- Haukeland Hospital, Norway
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- Carpen, Olli (author)
- University of Turku, Finland Turku University Hospital, Finland
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- Grove, Anni (author)
- Aarhus University Hospital, Denmark
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- Hansen, Estrid S. (author)
- Aarhus University Hospital, Denmark
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- Jakobsen, Anne-Marie Levin (author)
- Umeå University Hospital, Sweden
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- Lidang, Marianne (author)
- Herlev University Hospital, Denmark
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- Måsbäck, Anna (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Lund Hospital, Sweden
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- Tolf, Anna (author)
- Uppsala universitet,Molekylär och morfologisk patologi,University of Uppsala Hospital, Sweden
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- Gilks, C. Blake (author)
- Vancouver Gen Hospital, Canada University of British Columbia, Canada
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- Carlson, Joseph W. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2014-03-07
- 2014
- English.
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In: Histopathology. - : Wiley. - 0309-0167 .- 1365-2559. ; 94, s. 290A-290A
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Abstract
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- AimsTo assess the variation in ovarian carcinoma type diagnosis among gynaecological pathologists from Nordic countries, and whether a rationally designed panel of immunohistochemical markers could improve diagnostic reproducibility. Methods and resultsEight pathologists from four countries (Sweden, Denmark, Norway, and Finland) received an educational lecture on the diagnosis of ovarian carcinoma type. All tumour-containing slides from 54 ovarian carcinoma cases were independently reviewed by the participants, who: (i) determined type purely on the basis of histology; (ii) indicated whether they would apply immunohistochemistry in their routine practice; and (iii) determined type after reviewing the staining results. The results for six markers (WT1, p53, p16, HNF-1, ARID1A, and progesterone receptor) were determined for all 54 cases, by staining of a tissue microarray. The median concordance with central review diagnosis was 86%, and significantly improved to 90% with the incorporation of immunostaining results (P=0.0002). The median interobserver agreement was 78%, and significantly improved to 85% with the incorporation of immunostaining results (P=0.0002). ConclusionsUse of the immunostaining results significantly improved both diagnostic accuracy and interobserver agreement. These results indicate that ovarian carcinoma type can be reliably diagnosed by pathologists from different countries, and also demonstrate that immunohistochemistry has an important role in improving diagnostic accuracy and agreement between pathologists.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- clear cell adenocarcinoma
- cystic neoplasm
- endometrioid carcinoma
- mucinous neoplasm
- ovary
- reproducibility of results
- serous neoplasm
- clear cell adenocarcinoma
- cystic neoplasm
- endometrioid carcinoma
- mucinous neoplasm
- ovary
- reproducibility of results
- serous neoplasm
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Koebel, Martin
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Bak, Julia
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Bertelsen, Bjorn ...
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Carpen, Olli
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Grove, Anni
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Hansen, Estrid S ...
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Jakobsen, Anne-M ...
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Lidang, Marianne
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Måsbäck, Anna
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Tolf, Anna
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Gilks, C. Blake
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Carlson, Joseph ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Histopathology
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MODERN PATHOLOGY
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LABORATORY INVES ...
- By the university
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Uppsala University
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Lund University
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Linköping University
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Karolinska Institutet