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In vivo methods for...
In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects
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- Sjögren, Erik (author)
- Uppsala universitet,Institutionen för farmaci
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Abrahamsson, Bertil (author)
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Augustijns, Patrick (author)
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Becker, Dieter (author)
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Bolger, Michael B. (author)
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Brewster, Marcus (author)
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Brouwers, Joachim (author)
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Flanagan, Talia (author)
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Harwood, Matthew (author)
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Heinen, Christian (author)
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Holm, Rene (author)
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Juretschke, Hans-Paul (author)
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Kubbinga, Marlies (author)
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Lindahl, Anders (author)
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Lukacova, Viera (author)
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Munster, Uwe (author)
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Neuhoff, Sibylle (author)
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Nguyen, Mai Anh (author)
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van Peer, Achiel (author)
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Reppas, Christos (author)
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Hodjegan, Amin Rostami (author)
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Tannergren, Christer (author)
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Weitschies, Werner (author)
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Wilson, Clive (author)
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Zane, Patricia (author)
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- Lennernäs, Hans (author)
- Uppsala universitet,Institutionen för farmaci
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Langguth, Peter (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: European Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0928-0987 .- 1879-0720. ; 57, s. 99-151
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the existing in vivo models and demonstrate their usefulness in drug formulation and product performance testing. (c) 2014 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- In vivo model selection
- Biopharmaceutic characterization
- Bioavailability
- Drug product development
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sjögren, Erik
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Abrahamsson, Ber ...
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Augustijns, Patr ...
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Becker, Dieter
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Bolger, Michael ...
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Brewster, Marcus
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show more...
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Brouwers, Joachi ...
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Flanagan, Talia
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Harwood, Matthew
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Heinen, Christia ...
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Holm, Rene
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Juretschke, Hans ...
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Kubbinga, Marlie ...
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Lindahl, Anders
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Lukacova, Viera
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Munster, Uwe
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Neuhoff, Sibylle
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Nguyen, Mai Anh
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van Peer, Achiel
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Reppas, Christos
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Hodjegan, Amin R ...
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Tannergren, Chri ...
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Weitschies, Wern ...
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Wilson, Clive
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Zane, Patricia
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Lennernäs, Hans
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Langguth, Peter
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University