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The roles of transf...
The roles of transforming growth factor- similar to, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours ( Review)
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Bogaerts, Eliene (author)
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- Heindryckx, Femke (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Vandewynckel, Yves-Paul (author)
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Van Grunsven, Leo A. (author)
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Van Vlierberghe, Hans (author)
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(creator_code:org_t)
- 2014-02-03
- 2014
- English.
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In: International Journal of Oncology. - : Spandidos Publications. - 1019-6439 .- 1791-2423. ; 44:4, s. 1015-1022
- Related links:
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https://www.spandido...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Primary liver tumours have a high incidence and mortality. The most important forms are hepatocellular carcinoma and intrahepatic cholangiocarcinoma, both can occur together in the mixed phenotype hepatocellular-cholangiocarcinoma. Liver progenitor cells (LPCs) are bipotential stem cells activated in case of severe liver damage and are capable of forming both cholangiocytes and hepatocytes. Possibly, alterations in Wnt, transforming growth factor-, Notch and hypoxia pathways in these LPCs can cause them to give rise to cancer stem cells, capable of driving tumourigenesis. In this review, we summarize and discuss current knowledge on the role of these pathways in LPC activation and differentiation during hepatocarcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- hepatic cancer
- liver progenitor cell
- cancer stem cells
- Wnt receptors
- TGF-
- Notch receptors
- hypoxia inducible factor 1
Publication and Content Type
- ref (subject category)
- for (subject category)
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