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Probing Physical Pr...
Probing Physical Properties of a DNA-Protein Complex Using Nanofluidic Channels
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Frykholm, Karolin (author)
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Alizadehheidari, Mohammadreza (author)
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Fritzsche, Joachim (author)
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Wigenius, Jens (author)
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Nevin, Philip (author)
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Araya, Joshua (author)
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Beuning, Penny (author)
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Modesti, Mauro (author)
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- Persson, Fredrik (author)
- Uppsala universitet,Beräknings- och systembiologi
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Westerlund, Fredrik (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Biophysical Journal. - : Elsevier BV. - 0006-3495 .- 1542-0086. ; 106:2, s. 428A-429A
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Nanofluidic channels have become an important tool to investigate single DNA molecules both from a fundamental polymer physics perspective as well as in e.g. optical mapping techniques. However, less effort has been made to study DNA-protein complexes. A main reason is that the extreme surface-to-volume ratio in the nanochannels causes most proteins to stick to the channel walls. We have recently overcome this problem by coating the channels with a lipid bilayer, thereby eliminating sticking.
Subject headings
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Frykholm, Karoli ...
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Alizadehheidari, ...
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Fritzsche, Joach ...
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Wigenius, Jens
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Nevin, Philip
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Araya, Joshua
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show more...
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Beuning, Penny
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Modesti, Mauro
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Persson, Fredrik
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Westerlund, Fred ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
- Articles in the publication
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Biophysical Jour ...
- By the university
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Uppsala University