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Immunotherapy targeting alpha-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders
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- Lindström, Veronica (author)
- Uppsala universitet,Geriatrik
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- Ihse, Elisabet (author)
- Uppsala universitet,Geriatrik
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- Fagerqvist, Therese (author)
- Uppsala universitet,Geriatrik
- show more...
- Nordstrom, Eva (author)
- Moller, Christer (author)
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- (creator_code:org_t)
- 2014
- 2014
- English.
- In: Immunotherapy. - 1750-743X .- 1750-7448. ; 6:2, s. 141-153
- Research review (peer-reviewed)
Abstract
Subject headings
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- Immunotherapy targeting a-synuclein has evolved as a potential therapeutic strategy for neurodegenerative diseases, such as Parkinson's disease, and initial studies on cellular and animal models have shown promising results. alpha-synuclein vaccination of transgenic mice reduced the number of brain inclusions, whereas passive immunization studies demonstrated that antibodies against the C-terminus of alpha-synuclein can pass the blood-brain barrier and affect the pathology. In addition, preliminary evidence suggests that transgenic mice treated with an antibody directed against alpha-synuclein oligomers/protofibrils resulted in reduced levels of such species in the CNS. The underlying mechanisms of immunotherapy are not yet fully understood, but may include antibody-mediated clearance of pre-existing aggregates, prevention of protein propagation between cells and microglia-dependent protein clearance. Thus, immunotherapy targeting alpha-synuclein holds promise, but needs to be further developed as a future disease-modifying treatment in Parkinson's disease and other alpha-synucleinopathies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- alpha-synuclein
- antibody
- immunization
- immunotherapy
- Parkinson's disease
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