Sökning: onr:"swepub:oai:DiVA.org:uu-231114" > Coxsackievirus B1 R...
Fältnamn | Indikatorer | Metadata |
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000 | 03215naa a2200445 4500 | |
001 | oai:DiVA.org:uu-231114 | |
003 | SwePub | |
008 | 140904s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2311142 URI |
024 | 7 | a https://doi.org/10.1002/jmv.239032 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hamalainen, Sanna4 aut |
245 | 1 0 | a Coxsackievirus B1 Reveals Strain Specific Differences in Plasmacytoid Dendritic Cell Mediated Immunogenicity |
264 | c 2014-02-20 | |
264 | 1 | b Wiley,c 2014 |
338 | a print2 rdacarrier | |
520 | a Enterovirus infections are usually mild but can also cause severe illnesses and play a role in chronic diseases, such as cardiomyopathies and type 1 diabetes. Host response to the invading virus can markedly modulate the course of the infection, and this response varies between individuals due to the polymorphism of immune response genes. However, it is currently not known if virus strains also differ in their ability to stimulate the host immune system. Coxsackievirus B1 (CBV1) causes severe epidemics in young infants and it has recently been connected with type 1 diabetes in seroepidemiological studies. This study evaluated the ability of different field isolates of CBV1 to induce innate immune responses in PBMCs. CBV1 strains differed markedly in their capacity to induce innate immune responses. Out of the 18 tested CBV1 strains two induced exceptionally strong alpha interferon (IFN-alpha) response in PBMC cultures. The responding cell type was found to be the plasmacytoid dendritic cell. Such a strong innate immune response was accompanied by an up-regulation of several other immune response genes and secretion of cytokines, which modulate inflammation, and adaptive immune responses. These results suggest that enterovirus-induced immune activation depends on the virus strain. It is possible that the immunotype of the virus modulates the course of the infection and plays a role in the pathogenesis of chronic immune-mediated enterovirus diseases. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
653 | a coxsackievirus B1 (CBV1) | |
653 | a innate immunity | |
653 | a interferon-alpha (IFN-alpha) | |
653 | a pDC | |
700 | 1 | a Nurminen, Noora4 aut |
700 | 1 | a Ahlfors, Helena4 aut |
700 | 1 | a Oikarinen, Sami4 aut |
700 | 1 | a Sioofy-Khojine, Amir-Babak4 aut |
700 | 1 | a Frisk, Gunu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)gunfrisk |
700 | 1 | a Oberste, M. Steven4 aut |
700 | 1 | a Lahesmaa, Riitta4 aut |
700 | 1 | a Pesu, Marko4 aut |
700 | 1 | a Hyoty, Heikki4 aut |
710 | 2 | a Uppsala universitetb Klinisk immunologi4 org |
773 | 0 | t Journal of Medical Virologyd : Wileyg 86:8, s. 1412-1420q 86:8<1412-1420x 0146-6615x 1096-9071 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231114 |
856 | 4 8 | u https://doi.org/10.1002/jmv.23903 |
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