A prospective study on metabolic risk factors and gallbladder cancer in the metabolic syndrome and cancer (Me-Can) collaborative study

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A prospective study on metabolic risk factors and gallbladder cancer in the metabolic syndrome and cancer (Me-Can) collaborative study

Borena, Wegene (author)

Edlinger, Michael (author)

Bjørge, Tone (author)

Häggström, Christel (author): Umeå universitet,Urologi och andrologi

Lindkvist, Björn (author)

Nagel, Gabriele (author)

Engeland, Anders (author)

Stocks, Tanja (author): Umeå universitet,Umeå University,Urologi och andrologi,Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark

Strohmaier, Susanne (author)

Manjer, Jonas (author): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups

Selmer, Randi (author)

Tretli, Steinar (author)

Concin, Hans (author)

Hallmans, Göran (author): Umeå universitet,Enheten för biobanksforskning,Näringsforskning

Jonsson, Håkan (author): Umeå universitet,Onkologi

Stattin, Pär (author): Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi

Ulmer, Hanno (author)

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(creator_code:org_t)

2014-02-21
2014
English.
In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:2, s. e89368-

Related links:: https://journals.plo...; show more...; https://portal.resea... (primary) (free); http://www.ncbi.nlm....; http://dx.doi.org/10... (free); https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

OBJECTIVE:To investigate the association between metabolic risk factors (individually and in combination) and risk of gallbladder cancer (GBC).METHODS:The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden with data on 578,700 men and women. We used Cox proportional hazard regression models to calculate relative risks of GBC by body mass index (BMI), blood pressure, and plasma levels of glucose, cholesterol, and triglycerides as continuous standardised variables and their standardised sum of metabolic syndrome (MetS) z-score. The risk estimates were corrected for random error in measurements.RESULTS:During an average follow-up of 12.0 years (SD = 7.8), 184 primary gallbladder cancers were diagnosed. Relative risk of gallbladder cancer per unit increment of z-score adjusted for age, smoking status and BMI (except for BMI itself) and stratified by birth year, sex and sub-cohorts, was for BMI 1.31 (95% confidence interval 1.11, 1.57) and blood glucose 1.76 (1.10, 2.85). Further analysis showed that the effect of BMI on GBC risk is larger among women in the premenopausal age group (1.84 (1.23, 2.78)) compared to those in the postmenopausal age group (1.29 (0.93, 1.79)). For the other metabolic factors no significant association was found (mid blood pressure 0.96 (0.71, 1.31), cholesterol 0.84 (0.66, 1.06) and serum triglycerides 1.16 (0.82, 1.64)). The relative risk per one unit increment of the MetS z-score was 1.37 (1.07, 1.73).CONCLUSION:This study showed that increasing BMI and impaired glucose metabolism pose a possible risk for gallbladder cancer. Beyond the individual factors, the results also showed that the metabolic syndrome as an entity presents a risk constellation for the occurrence of gallbladder cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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By the author/editor: Borena, Wegene; Edlinger, Michae ...; Bjørge, Tone; Häggström, Chris ...; Lindkvist, Björn; Nagel, Gabriele; show more...; Engeland, Anders; Stocks, Tanja; Strohmaier, Susa ...; Manjer, Jonas; Selmer, Randi; Tretli, Steinar; Concin, Hans; Hallmans, Göran; Jonsson, Håkan; Stattin, Pär; Ulmer, Hanno; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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By the university: Uppsala University; Lund University; Umeå University

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