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Rabbit genome analy...
Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
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Carneiro, Miguel (author)
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- Rubin, Carl-Johan (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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Di Palma, Federica (author)
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Albert, Frank W. (author)
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Alfoeldi, Jessica (author)
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- Barrio, Alvaro Martinez (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi
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- Pielberg, Gerli (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Rafati, Nima (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi
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- Sayyab, Shumaila (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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Turner-Maier, Jason (author)
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- Younis, Shady (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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Afonso, Sandra (author)
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Aken, Bronwen (author)
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Alves, Joel M. (author)
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Barrell, Daniel (author)
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Bolet, Gerard (author)
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Boucher, Samuel (author)
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Burbano, Hernan A. (author)
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Campos, Rita (author)
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Chang, Jean L. (author)
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Duranthon, Veronique (author)
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Fontanesi, Luca (author)
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Garreau, Herve (author)
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Heiman, David (author)
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Johnson, Jeremy (author)
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Mage, Rose G. (author)
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Peng, Ze (author)
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Queney, Guillaume (author)
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Rogel-Gaillard, Claire (author)
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Ruffier, Magali (author)
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Searle, Steve (author)
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Villafuerte, Rafael (author)
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- Xiong, Anqi (author)
- Uppsala universitet,Cancer och vaskulärbiologi,Science for Life Laboratory, SciLifeLab
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Young, Sarah (author)
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- Forsberg-Nilsson, Karin (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancer och vaskulärbiologi
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Good, Jeffrey M. (author)
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Lander, Eric S. (author)
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Ferrand, Nuno (author)
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- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University,Texas A&M University
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(creator_code:org_t)
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- American Association for the Advancement of Science (AAAS), 2014
- 2014
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 345:6200, s. 1074-1079
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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Abstract
Subject headings
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- The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Science
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To the university's database
- By the author/editor
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Carneiro, Miguel
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Rubin, Carl-Joha ...
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Di Palma, Federi ...
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Albert, Frank W.
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Alfoeldi, Jessic ...
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Barrio, Alvaro M ...
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show more...
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Pielberg, Gerli
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Rafati, Nima
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Sayyab, Shumaila
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Turner-Maier, Ja ...
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Younis, Shady
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Afonso, Sandra
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Aken, Bronwen
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Alves, Joel M.
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Barrell, Daniel
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Bolet, Gerard
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Boucher, Samuel
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Burbano, Hernan ...
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Campos, Rita
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Chang, Jean L.
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Duranthon, Veron ...
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Fontanesi, Luca
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Garreau, Herve
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Heiman, David
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Johnson, Jeremy
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Mage, Rose G.
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Peng, Ze
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Queney, Guillaum ...
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Rogel-Gaillard, ...
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Ruffier, Magali
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Searle, Steve
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Villafuerte, Raf ...
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Xiong, Anqi
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Young, Sarah
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Forsberg-Nilsson ...
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Good, Jeffrey M.
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Lander, Eric S.
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Ferrand, Nuno
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Lindblad-Toh, Ke ...
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Andersson, Leif
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Science
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences