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Rabbit genome analy...
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Carneiro, Miguel
(author)
Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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American Association for the Advancement of Science (AAAS),2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-232593
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-232593URI
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https://doi.org/10.1126/science.1253714DOI
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https://res.slu.se/id/publ/67862URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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De två sista författarna delar sistaförfattarskapet (Andersson och Lindblad-Toh)
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The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Rubin, Carl-JohanUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)carub021
(author)
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Di Palma, Federica
(author)
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Albert, Frank W.
(author)
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Alfoeldi, Jessica
(author)
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Barrio, Alvaro MartinezUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)almar255
(author)
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Pielberg, GerliUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)gepie020
(author)
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Rafati, NimaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)nimra236
(author)
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Sayyab, ShumailaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics(Swepub:slu)93482
(author)
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Turner-Maier, Jason
(author)
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Younis, ShadyUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)shayo804
(author)
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Afonso, Sandra
(author)
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Aken, Bronwen
(author)
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Alves, Joel M.
(author)
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Barrell, Daniel
(author)
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Bolet, Gerard
(author)
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Boucher, Samuel
(author)
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Burbano, Hernan A.
(author)
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Campos, Rita
(author)
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Chang, Jean L.
(author)
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Duranthon, Veronique
(author)
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Fontanesi, Luca
(author)
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Garreau, Herve
(author)
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Heiman, David
(author)
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Johnson, Jeremy
(author)
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Mage, Rose G.
(author)
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Peng, Ze
(author)
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Queney, Guillaume
(author)
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Rogel-Gaillard, Claire
(author)
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Ruffier, Magali
(author)
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Searle, Steve
(author)
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Villafuerte, Rafael
(author)
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Xiong, AnqiUppsala universitet,Cancer och vaskulärbiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)anqxi804
(author)
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Young, Sarah
(author)
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Forsberg-Nilsson, KarinUppsala universitet,Science for Life Laboratory, SciLifeLab,Cancer och vaskulärbiologi(Swepub:uu)karifors
(author)
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Good, Jeffrey M.
(author)
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Lander, Eric S.
(author)
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Ferrand, Nuno
(author)
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Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)kerli865
(author)
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Andersson, LeifSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University,Texas A&M University(Swepub:slu)48730
(author)
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
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Sveriges lantbruksuniversitet
Related titles
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In:Science: American Association for the Advancement of Science (AAAS)345:6200, s. 1074-10790036-80751095-9203
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Carneiro, Miguel
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Rubin, Carl-Joha ...
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Di Palma, Federi ...
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Albert, Frank W.
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Alfoeldi, Jessic ...
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Barrio, Alvaro M ...
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Pielberg, Gerli
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Rafati, Nima
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Sayyab, Shumaila
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Turner-Maier, Ja ...
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Younis, Shady
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Afonso, Sandra
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Aken, Bronwen
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Alves, Joel M.
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Barrell, Daniel
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Bolet, Gerard
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Boucher, Samuel
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Burbano, Hernan ...
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Campos, Rita
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Chang, Jean L.
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Duranthon, Veron ...
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Fontanesi, Luca
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Garreau, Herve
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Heiman, David
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Johnson, Jeremy
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Mage, Rose G.
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Peng, Ze
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Queney, Guillaum ...
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Rogel-Gaillard, ...
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Ruffier, Magali
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Searle, Steve
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Villafuerte, Raf ...
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Xiong, Anqi
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Young, Sarah
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Forsberg-Nilsson ...
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Good, Jeffrey M.
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Lander, Eric S.
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Ferrand, Nuno
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Lindblad-Toh, Ke ...
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Andersson, Leif
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Swedish University of Agricultural Sciences