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Influence of a prud...
Influence of a prudent diet on circulating cathepsin S in humans
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- Jobs, Elisabeth (author)
- Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap,Uppsala universitetet
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- Adamsson, Viola (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Larsson, Anders (author)
- Uppsala universitet,Biokemisk struktur och funktion
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- Jobs, Magnus (author)
- Högskolan Dalarna,Medicinsk vetenskap
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- Nerpin, Elisabet (author)
- Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi
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- Ärnlöv, Johan (author)
- Högskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Medicinsk vetenskap
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- Risérus, Ulf (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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(creator_code:org_t)
- 2014-08-16
- 2014
- English.
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In: Nutrition Journal. - : Springer Science and Business Media LLC. - 1475-2891. ; 13, s. 84-
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Abstract
Subject headings
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- Background: Increased circulating cathepsin S levels have been linked to increased risk of cardiometabolic diseases and cancer. However, whether cathepsin S is a modifiable risk factor is unclear. We aimed to investigate the effects of a prudent diet on plasma cathepsin S levels in healthy individuals. Findings: Explorative analyses of a randomized study were performed in 88 normal to slightly overweight and hyperlipidemic men and women (aged 25 to 65) that were randomly assigned to ad libitum prudent diet, i.e. healthy Nordic diet (ND) or a control group (habitual Western diet) for 6 weeks. Whereas all foods in the ND were provided, the control group was advised to consume their habitual diet throughout the study. The ND was in line with dietary recommendations, e. g. low in saturated fats, sugars and salt, but high in plant-based foods rich in fibre and unsaturated fats. The ND significantly decreased cathepsin S levels (from 20.1 (+/-4.0 SD) to 19.7 mu g/L (+/-4.3 SD)) compared with control group (from 18.2 (+/-2.9 SD) to 19.1 mu g/L (+/-3.8 SD)). This difference remained after adjusting for sex and change in insulin sensitivity (P = 0.03), and near significant after adjusting for baseline cathepsin S levels (P = 0.06), but not for change in weight or LDL-C. Changes in cathepsin S levels were directly correlated with change in LDL-C. Conclusions: Compared with a habitual control diet, a provided ad libitum healthy Nordic diet decreased cathepsin S levels in healthy individuals, possibly mediated by weight loss or lowered LDL-C. These differences between groups in cathepsin S were however not robust and therefore need further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Nordic prudent diet
- Cathepsin S
- Weight loss
- Cardiometabolic risk factors
- Hälsa och välfärd
Publication and Content Type
- ref (subject category)
- art (subject category)
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