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Vitamin D and Endot...
Vitamin D and Endothelial Vasodilation in Older Individuals : Data From the PIVUS Study
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Maggio, Marcello (author)
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De Vita, Francesca (author)
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Lauretani, Fulvio (author)
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Ceda, Gian Paolo (author)
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Volpi, Elena (author)
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Giallauria, Francesco (author)
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De Cicco, Giuseppe (author)
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Cattabiani, Chiara (author)
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- Melhus, Håkan (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos
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- Michaëlsson, Karl (author)
- Uppsala universitet,Ortopedi
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- Cederholm, Tommy (author)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism
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- Lind, Lars (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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(creator_code:org_t)
- The Endocrine Society, 2014
- 2014
- English.
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In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 99:9, s. 3382-3389
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- CONTEXT:Vitamin D plays a role in a wide range of extraskeletal processes, including vascular function. Endothelial dysfunction is a predictor of cardiovascular disease, especially in older subjects. However, the relationship between vitamin D levels and indexes of endothelial vasodilation has never been fully addressed in older individuals.OBJECTIVE:The objective of this study was to examine the association between vitamin D and endothelial function in a large community-based sample of older subjects.METHODS:This cross-sectional study involved 852 community-dwelling men and women aged 70 years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), with complete data on vascular function and 25-hydroxyvitamin D. We evaluated endothelium-dependent vasodilation by an invasive forearm technique with acetylcholine, endothelium-independent vasodilation by sodium nitroprussiate, flow-mediated vasodilation, and the pulse wave analysis (reflectance index). Vitamin D levels were measured by chemiluminescence. We used multivariate regression models adjusted for body mass index (model 1) and for multiple confounders (high-sensitivity C-reactive protein, insulin, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, smoking, sex hormones, season of blood collection, hypertension, diabetes, cardiovascular medications and diseases, statin usage, plasma calcium and calcium intake, PTH, physical exercise, liver and kidney function tests, albumin; model 2).RESULTS:In women, but not in men, vitamin D levels were positively associated with endothelium-independent vasodilation in both model 1 (β ± SE = 1.41 ± 0.54; P = .001), and model 2 (β ± SE = 2.01 ± 0.68; P = .003).We found no significant relationship between vitamin D levels and endothelium-dependent vasodilation, flow-mediated vasodilation, and reflectance index in both sexes.CONCLUSIONS:In older women, but not in men, vitamin D is positively and independently associated with EIDV.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Maggio, Marcello
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De Vita, Frances ...
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Lauretani, Fulvi ...
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Ceda, Gian Paolo
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Volpi, Elena
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Giallauria, Fran ...
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show more...
-
De Cicco, Giusep ...
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Cattabiani, Chia ...
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Melhus, Håkan
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Michaëlsson, Kar ...
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Cederholm, Tommy
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Lind, Lars
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Journal of Clini ...
- By the university
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Uppsala University
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Karolinska Institutet