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Genome-wide associa...
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Fall, ToveDept. of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden
(author)
Genome-wide association studies of obesity and metabolic syndrome
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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Elsevier BV,2014
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LIBRIS-ID:oai:DiVA.org:uu-233665
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233665URI
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https://doi.org/10.1016/j.mce.2012.08.018DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128218758URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were largely unknown, with the exception of a few forms of monogenic extreme obesity. Since genome-wide association studies (GWAS) became available, large advances have been made. The first single nucleotide polymorphism robustly associated with increased body mass index (BMI) was in 2007 mapped to a gene with for the time unknown function. This gene, now known as fat mass and obesity associated (FTO) has been repeatedly replicated in several ethnicities and is affecting obesity by regulating appetite. Since the first report from a GWAS of obesity, an increasing number of markers have been shown to be associated with BMI, other measures of obesity or fat distribution and metabolic syndrome. This systematic review of obesity GWAS will summarize genome-wide significant findings for obesity and metabolic syndrome and briefly give a few suggestions of what is to be expected in the next few years.
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Ingelsson, ErikDept. of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden(Swepub:uu)ering425
(author)
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Dept. of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden
(creator_code:org_t)
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In:Molecular and Cellular Endocrinology: Elsevier BV382:1, s. 740-7570303-72071872-8057
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