Search: onr:"swepub:oai:DiVA.org:uu-234208" >
A cis-Regulatory Mu...
A cis-Regulatory Mutation of PDSS2 Causes Silky-Feather in Chickens
-
Feng, Chungang (author)
-
Gao, Yu (author)
-
- Dorshorst, Ben (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
-
show more...
-
Song, Chi (author)
-
Gu, Xiaorong (author)
-
Li, Qingyuan (author)
-
Li, Jinxiu (author)
-
Liu, Tongxin (author)
-
- Rubin, Carl-Johan (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
-
Zhao, Yiqiang (author)
-
Wang, Yanqiang (author)
-
Fei, Jing (author)
-
Li, Huifang (author)
-
Chen, Kuanwei (author)
-
Qu, Hao (author)
-
Shu, Dingming (author)
-
Ashwell, Chris (author)
-
Da, Yang (author)
-
- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
-
Hu, Xiaoxiang (author)
-
Li, Ning (author)
-
show less...
-
(creator_code:org_t)
-
- 2014-08-28
- 2014
- English.
-
In: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 10:8, s. e1004576-
- Related links:
-
https://uu.diva-port... (primary) (Raw object)
-
show more...
-
https://journals.plo...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://res.slu.se/i...
-
show less...
Abstract
Subject headings
Close
- Silky-feather has been selected and fixed in some breeds due to its unique appearance. This phenotype is caused by a single recessive gene (hookless, h). Here we map the silky-feather locus to chromosome 3 by linkage analysis and subsequently fine-map it to an 18.9 kb interval using the identical by descent (IBD) method. Further analysis reveals that a C to G transversion located upstream of the prenyl (decaprenyl) diphosphate synthase, subunit 2 (PDSS2) gene is causing silky-feather. All silky-feather birds are homozygous for the G allele. The silky-feather mutation significantly decreases the expression of PDSS2 during feather development in vivo. Consistent with the regulatory effect, the C to G transversion is shown to remarkably reduce PDSS2 promoter activity in vitro. We report a new example of feather structure variation associated with a spontaneous mutation and provide new insight into the PDSS2 function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Feng, Chungang
-
Gao, Yu
-
Dorshorst, Ben
-
Song, Chi
-
Gu, Xiaorong
-
Li, Qingyuan
-
show more...
-
Li, Jinxiu
-
Liu, Tongxin
-
Rubin, Carl-Joha ...
-
Zhao, Yiqiang
-
Wang, Yanqiang
-
Fei, Jing
-
Li, Huifang
-
Chen, Kuanwei
-
Qu, Hao
-
Shu, Dingming
-
Ashwell, Chris
-
Da, Yang
-
Andersson, Leif
-
Hu, Xiaoxiang
-
Li, Ning
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Genetics
- Articles in the publication
-
PLOS Genetics
- By the university
-
Uppsala University
-
Swedish University of Agricultural Sciences