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The Clinical Pharma...
The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy : 2014 Update
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Ramsey, L. B. (author)
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Johnson, S. G. (author)
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Caudle, K. E. (author)
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Haidar, C. E. (author)
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Voora, D. (author)
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Wilke, R. A. (author)
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Maxwell, W. D. (author)
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McLeod, L. (author)
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Krauss, R. M. (author)
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Roden, D. M. (author)
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Feng, Q. (author)
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Cooper-DeHoff, R. M. (author)
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Gong, L. (author)
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Klein, T. E. (author)
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- Wadelius, Mia (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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Niemi, M. (author)
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(creator_code:org_t)
- 2014-06-11
- 2014
- English.
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In: Clinical Pharmacology and Therapeutics. - : Springer Science and Business Media LLC. - 0009-9236 .- 1532-6535. ; 96:4, s. 423-428
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for simvastatin based on SLCO1B1 genotype. This article is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium guideline for SLCO1B1 and simvastatin-induced myopathy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ramsey, L. B.
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Johnson, S. G.
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Caudle, K. E.
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Haidar, C. E.
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Voora, D.
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Wilke, R. A.
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show more...
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Maxwell, W. D.
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McLeod, L.
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Krauss, R. M.
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Roden, D. M.
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Feng, Q.
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Cooper-DeHoff, R ...
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Gong, L.
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Klein, T. E.
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Wadelius, Mia
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Niemi, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Clinical Pharmac ...
- By the university
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Uppsala University