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Early Failure of Fr...
Early Failure of Frontline Rituximab-Containing Chemo-immunotherapy in Diffuse Large B Cell Lymphoma Does Not Predict Futility of Autologous Hematopoietic Cell Transplantation
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Hamadani, Mehdi (author)
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Hari, Parameswaran N. (author)
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Zhang, Ying (author)
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Carreras, Jeanette (author)
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Akpek, Goerguen (author)
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Aljurf, Mahmoud D. (author)
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Ayala, Ernesto (author)
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Bachanova, Veronika (author)
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Chen, Andy I. (author)
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Chen, Yi-Bin (author)
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Costa, Luciano J. (author)
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Fenske, Timothy S. (author)
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Freytes, Cesar O. (author)
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Ganguly, Siddhartha (author)
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Hertzberg, Mark S. (author)
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Holmberg, Leona A. (author)
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Inwards, David J. (author)
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Kamble, Rammurti T. (author)
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Kanfer, Edward J. (author)
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Lazarus, Hillard M. (author)
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Marks, David I. (author)
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Nishihori, Taiga (author)
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- Olsson, Richard (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)
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Reddy, Nishitha M. (author)
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Rizzieri, David A. (author)
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Savani, Bipin N. (author)
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Solh, Melhem (author)
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Vose, Julie M. (author)
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Wirk, Baldeep (author)
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Maloney, David G. (author)
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Smith, Sonali M. (author)
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Montoto, Silvia (author)
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Saber, Wael (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 20:11, s. 1729-1736
- Related links:
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http://www.bbmt.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- The poor prognosis for patients with diffuse large B cell lymphoma (DLBCL) who relapse within 1 year of initial diagnosis after first-line rituximab-based chemo-immunotherapy has created controversy about the role of autologous transplantation (HCT) in this setting. We compared autologous HCT outcomes for chemosensitive DLBCL patients between 2000 and 2011 in 2 cohorts based on time to relapse from diagnosis. The early rituximab failure (ERF) cohort consisted of patients with primary refractory disease or those with first relapse within 1 year of initial diagnosis. The ERF cohort was compared with those relapsing >1 year after initial diagnosis (late rituximab failure [LRF] cohort). ERF and LRF cohorts included 300 and 216 patients, respectively. Nonrelapse mortality (NRM), progression/relapse, progression-free survival (PFS), and overall survival (OS) of ERF versus LRF cohorts at 3 years were 9% (95% confidence interval [CI], 6% to 13%) versus 9% (95% CI, 5% to 13%), 47% (95% CI, 41% to 52%) versus 39% (95% CI, 33% to 46%), 44% (95% CI, 38% to 50%) versus 52% (95% CI, 45% to 59%), and 50% (95% CI, 44% to 56%) versus 67% (95% CI, 60% to 74%), respectively. On multivariate analysis, ERF was not associated with higher NRM (relative risk [RR], 1.31; P = .34). The ERF cohort had a higher risk of treatment failure (progression/relapse or death) (RR, 2.08; P < .001) and overall mortality (RR, 3.75; P < .001) within the first 9 months after autologous HCT. Beyond this period, PFS and OS were not significantly different between the ERF and LRF cohorts. Autologous HCT provides durable disease control to a sizeable subset of DLBCL despite ERF (3-year PFS, 44%) and remains the standard-of-care in chemosensitive DLBCL regardless of the timing of disease relapse.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Autologous transplantation
- Rituximab
- Early failure
- High-dose therapy
- Diffuse large B cell lymphoma
- Aggressive lymphoma
- Non-Hodgkin lymphoma
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hamadani, Mehdi
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Hari, Parameswar ...
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Zhang, Ying
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Carreras, Jeanet ...
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Akpek, Goerguen
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Aljurf, Mahmoud ...
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show more...
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Ayala, Ernesto
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Bachanova, Veron ...
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Chen, Andy I.
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Chen, Yi-Bin
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Costa, Luciano J ...
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Fenske, Timothy ...
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Freytes, Cesar O ...
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Ganguly, Siddhar ...
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Hertzberg, Mark ...
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Holmberg, Leona ...
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Inwards, David J ...
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Kamble, Rammurti ...
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Kanfer, Edward J ...
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Lazarus, Hillard ...
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Marks, David I.
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Nishihori, Taiga
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Olsson, Richard
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Reddy, Nishitha ...
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Rizzieri, David ...
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Savani, Bipin N.
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Solh, Melhem
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Vose, Julie M.
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Wirk, Baldeep
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Maloney, David G ...
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Smith, Sonali M.
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Montoto, Silvia
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Saber, Wael
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Biology of blood ...
- By the university
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Uppsala University
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Karolinska Institutet