Search: onr:"swepub:oai:DiVA.org:uu-236746" >
Controlling Osteoge...
Controlling Osteogenic Differentiation through Nanoporous Alumina
-
- Pujari-Palmer, Shiuli (author)
- Uppsala universitet,Tillämpad materialvetenskap
-
- Lind, Thomas (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos
-
- Xia, Wei (author)
- Uppsala universitet,Tillämpad materialvetenskap
-
show more...
-
- Tang, Liping (author)
- University of Texas at Arlington
-
- Karlsson Ott, Marjam (author)
- Uppsala universitet,Tillämpad materialvetenskap
-
show less...
-
(creator_code:org_t)
- Scientific Research Publishing, Inc. 2014
- 2014
- English.
-
In: Journal of Biomaterials and Nanobiotechnology. - : Scientific Research Publishing, Inc.. - 2158-7027 .- 2158-7043. ; 5:2, s. 98-104
- Related links:
-
http://www.scirp.org...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.4...
-
show less...
Abstract
Subject headings
Close
- Nanotopographical features are found to have significant effects on bone behavior. In the presentstudy, nanoporous aluminas with different pore sizes (20, 100 and 200 nm in diameter), were eva-luated for their osteoinductive and drug eluting properties. W20-17 marrow stromal cells wereseeded on nanoporous alumina with and without the addition of BMP-2. Although cell prolifera-tion was not affected by pore size, osteogenic differentiation was 200 nm as compared to 20 and100 nm pores induced higher alkaline phosphatase activity (ALP) and osteocalcin expression le-vels, thus indicating osteoblastic differentiation. Cell morphology revealed that cells cultured on20 nm pores adopted a rounded shape, while larger pores (200 nm) elicited an elongated morpho-logy. Furthermore, ALP expression levels were consistently higher on BMP-2 loaded nanoporousalumina surfaces compared to unloaded surfaces, indicating that not only is nanoporous aluminaosteoinductive, but also has the potential to be used as a drug eluting bone-implant coating.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database