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A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.
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- Sim, Sarah C (author)
- Karolinska Institutet
- Risinger, Carl (author)
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- Dahl, Marja-Liisa (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Pharmacogenetics
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- Christensen, Magnus (author)
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- (creator_code:org_t)
- Springer Science and Business Media LLC, 2006
- 2006
- English.
- In: Clin Pharmacol Ther. - : Springer Science and Business Media LLC. - 0009-9236. ; 79:1, s. 103-13
- Journal article (peer-reviewed)
Subject headings
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Keyword
- Animals
- Anticonvulsants/pharmacokinetics
- Antidepressive Agents/*pharmacokinetics/therapeutic use
- Aryl Hydrocarbon Hydroxylases/*genetics
- China/epidemiology
- Electrophoretic Mobility Shift Assay
- Enzyme Inhibitors/*pharmacokinetics/therapeutic use
- Ethiopia/epidemiology
- Gene Frequency
- Genes; Reporter/genetics
- Genotype
- Humans
- Male
- Mephenytoin/pharmacokinetics
- Mice
- Mixed Function Oxygenases/*genetics
- Mutation
- Omeprazole/pharmacokinetics/therapeutic use
- Phenotype
- Plasmids/genetics
- Proton Pumps/*antagonists & inhibitors
- Reverse Transcriptase Polymerase Chain Reaction
- Sweden/epidemiology
- Transfection
- Variation (Genetics)
Publication and Content Type
- ref (subject category)
- art (subject category)
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