Sökning: onr:"swepub:oai:DiVA.org:uu-23780" >
Placental transfer ...
Placental transfer of quetiapine in relation to P-glycoprotein activity
-
Rahi, Melissa (författare)
-
Heikkinen, Tuija (författare)
-
Härtter, Sebastian (författare)
-
visa fler...
-
Hakkola, Jukka (författare)
-
Hakala, Kristo (författare)
-
- Wallerman, Ola (författare)
- Uppsala universitet,Institutionen för genetik och patologi,Wadelius
-
- Wadelius, Mia (författare)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos
-
- Wadelius, Claes (författare)
- Uppsala universitet,Institutionen för genetik och patologi,Wadelius
-
Laine, Kari (författare)
-
visa färre...
-
(creator_code:org_t)
- 2006-11-08
- 2007
- Engelska.
-
Ingår i: Journal of Psychopharmacology. - : SAGE Publications. - 0269-8811 .- 1461-7285. ; 21:7, s. 751-756
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Atypical antipsychotic drugs are well tolerated and thus often preferred in women of fertile age; yet the information on their placental transfer and use during the prenatal period is limited. The aim of this study was to study the placental transfer of quetiapine, a widely used atypical antipsychotic, with special reference to the role of the placental transporter protein, P-glycoprotein (P-gp). This was performed in 18 dually perfused placentas, using the well established P-gp inhibitors PSC833 (valspodar) and GG918 to inhibit the function of P-gp. We also aimed to clarify the significance of two potentially functional ABCB1 single nuclear polymorphisms (SNPs), 2677G>T/A and 3435C>T, on the transplacental transfer (TPT) of quetiapine. The placental transfer of quetiapine in the control group as measured by TPTAUC % (absolute fraction of the dose crossing placenta) was 3.7%, which is 29% less than the transfer of the freely diffusible antipyrine, which was 5.2%. The P-gp inhibitors had no significant effect on the transfer of quetiapine as measured by TPTAUC % (P = 0.77). No correlation was found between the transplacental transfer of quetiapine (TPTAUC %) and placental P-gp expression (P = 0.61). The 3435T allele in exon 26 was associated with significantly higher placental transfer of quetiapine (P = 0.04). We conclude that quetiapine passes the human placenta but that the blood-placental barrier partially limits the transplacental transfer of quetiapine. Administration of P-gp inhibiting drugs with quetiapine is not likely to increase fetal exposure to quetiapine, although the ABCB1 C3435T polymorphism may contribute to inter-individual variation in fetal exposure to quetiapine.
Nyckelord
- p-glycoprotein
- ABCB1
- MDR1
- placental transfer
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas