GABA and its B-receptor are present at the node of Ranvier in a small population of sensory fibers, implicating a role in myelination

The γ-aminobutyric acid (GABA) type B receptor has been implicated in glial cell development in the peripheral nervous system (PNS), although the exact function of GABA signaling is not known. To investigate GABA and its B receptor in PNS development and degeneration, we studied the expression of the GABAB receptor, GABA, and glutamic acid decarboxylase GAD65/67 in both development and injury in fetal dissociated dorsal root ganglia (DRG) cell cultures and in the rat sciatic nerve. We found that GABA, GAD65/67, and the GABAB receptor were expressed in premyelinating and nonmyelinating Schwann cells throughout development and after injury. A small population of myelinated sensory fibers displayed all of these molecules at the node of Ranvier, indicating a role in axon-glia communication. Functional studies using GABAB receptor agonists and antagonists were performed in fetal DRG primary cultures to study the function of this receptor during development. The results show that GABA, via its B receptor, is involved in the myelination process but not in Schwann cell proliferation. The data from adult nerves suggest additional roles in axon-glia communication after injury.

Wicher, GrzegorzUppsala universitet,Institutionen för neurovetenskap,Institutionen för immunologi, genetik och patologi(Swepub:uu)grwic173 (author)
Radomska, Katarzyna JUppsala universitet,Institutionen för organismbiologi (author)
Dağlıkoca, E Duygu (author)
Godskesen, Randi Elberg (author)
Fredriksson, RobertUppsala universitet,Funktionell farmakologi(Swepub:uu)rfr20930 (author)
Benedikz, Eirikur (author)
Magnaghi, Valerio (author)
Fex Svenningsen, ÅsaUppsala universitet,Institutionen för neurovetenskap (author)
Uppsala universitetInstitutionen för neurovetenskap (creator_code:org_t)

By the author/editor: Corell, Mikael; Wicher, Grzegorz; Radomska, Katarz ...; Dağlıkoca, E Duy ...; Godskesen, Randi ...; Fredriksson, Rob ...; show more...; Benedikz, Eiriku ...; Magnaghi, Valeri ...; Fex Svenningsen, ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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