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Psychosis in patien...
Psychosis in patients with narcolepsy as an adverse effect of sodium oxybate
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- Sarkanen, Tomi (författare)
- Cent Finland Cent Hosp, Dept Neurol, Jyvaskyla 40620, Finland; Vitalmed Res Ctr, Helsinki Sleep Clin, Helsinki, Finland
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- Niemelä, Valter (författare)
- Uppsala universitet,Neurologi,Uppsala , Sweden
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- Landtblom, Anne-Marie (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Uppsala universitet,Neurologi,Linkoping Univ Hosp, Dept Neurol, S-58185 Linkoping, Sweden,Avdelningen för neurovetenskap,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Neurologiska kliniken
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- Partinen, Markku (författare)
- Vitalmed Res Ctr, Helsinki Sleep Clin, Helsinki, Finland; Univ Helsinki, Dept Clin Neurosci, Helsinki, Finland,University of Helsinki, Helsinki, Finland
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(creator_code:org_t)
- 2014-08-20
- 2014
- Engelska.
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Ingår i: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 5
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- AIM: Hypnagogic and hypnopompic hallucinations are characteristic symptoms of narcolepsy, as are excessive daytime sleepiness, cataplexy, and sleep paralysis. Narcolepsy patients may also experience daytime hallucinations unrelated to sleep-wake transitions. The effect of medication on hallucinations is of interest since treatment of narcolepsy may provoke psychotic symptoms. We aim to analyze the relation between sodium oxybate (SXB) treatment and psychotic symptoms in narcolepsy patients. Furthermore, we analyze the characteristics of hallucinations to determine their nature as mainly psychotic or hypnagogic and raise a discussion about whether SXB causes psychosis or if psychosis occurs as an endogenous complication in narcolepsy.METHOD: We present altogether four patients with narcolepsy who experienced psychotic symptoms during treatment with SXB. In addition, we searched the literature for descriptions of hallucinations in narcolepsy and similarities and differences with psychotic symptoms in schizophrenia.RESULTS: Three out of four patients had hallucinations typical for psychosis and one had symptoms that resembled aggravated hypnagogic hallucinations. Two patients also had delusional symptoms primarily associated with mental disorders. Tapering down SXB was tried and helped in two out of four cases. Adding antipsychotic treatment (risperidone) alleviated psychotic symptoms in two cases.CONCLUSION: Psychotic symptoms in narcolepsy may appear during SXB treatment. Hallucinations resemble those seen in schizophrenia; however, the insight that symptoms are delusional is usually preserved. In case of SXB-induced psychotic symptoms or hallucinations, reducing SXB dose or adding antipsychotic medication can be tried.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)
Nyckelord
- xyrem
- sodium oxybate
- gamma hydroxybutyrate
- psychosis
- hallucinations
- narcolepsy
- schizophrenia
- sleep disorders
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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