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  • Alafuzoff, IrinaUppsala universitet,Institutionen för immunologi, genetik och patologi (author)

Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions : an inter-laboratory study by the BrainNet Europe consortium

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2014-09-20
  • Springer Science and Business Media LLC,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-239546
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239546URI
  • https://doi.org/10.1007/s00702-014-1304-1DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:131661996URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Correction in: Journal of Neural Transmission, 2014, vol. 122, issue 7, pages 973-974, DOI: 10.1007/s00702-014-1337-5
  • The BrainNet Europe consortium assessed the reproducibility in the assignment of the type of frontotemporal lobar degeneration (FTLD) with TAR DNA-binding protein (TDP) 43 following current recommendations. The agreement rates were influenced by the immunohistochemical (IHC) method and by the classification strategy followed. p62-IHC staining yielded good uniform quality of stains, but the most reliable results were obtained implementing specific Abs directed against the hallmark protein TDP43. Both assessment of the type and the extent of lesions were influenced by the Abs and by the quality of stain. Assessment of the extent of the lesions yielded poor results repeatedly; thus, the extent of pathology should not be used in diagnostic consensus criteria. Whilst 31 neuropathologists typed 30 FTLD-TDP cases, inter-rater agreement ranged from 19 to 100 per cent, being highest when applying phosphorylated TDP43/IHC. The agreement was highest when designating Type C or Type A/B. In contrast, there was a poor agreement when attempting to separate Type A or Type B FTLD-TDP. In conclusion, we can expect that neuropathologist, independent of his/her familiarity with FTLD-TDP pathology, can identify a TDP43-positive FTLD case. The goal should be to state a Type (A, B, C, D) or a mixture of Types (A/B, A/C or B/C). Neuropathologists, other clinicians and researchers should be aware of the pitfalls whilst doing so. Agreement can be reached in an inter-laboratory setting regarding Type C cases with thick and long neurites, whereas the differentiation between Types A and B may be more troublesome.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Pikkarainen, MariaUniv Eastern Finland, Dept Clin Med, Kuopio, Finland (author)
  • Neumann, ManuelaUniv Tubingen, German Ctr Neurodegenerat Dis, Dept Neuropatol, Tubingen, Germany; DZNE, Tubingen, Germany (author)
  • Arzberger, ThomasUniv Munich, Ctr Neuropathol & Prion Res, Munich, Germany (author)
  • Al-Sarraj, SafaKings Coll Hosp London, Inst Psychiat, Dept Clin Neuropathol, London, England; MRC, London Neurodegenerat Dis Brain Bank, London, England (author)
  • Bodi, IstvanKings Coll Hosp London, Inst Psychiat, Dept Clin Neuropathol, London, England; MRC, London Neurodegenerat Dis Brain Bank, London, England (author)
  • Bogdanovic, NenadKarolinska Institutet (author)
  • Bugiani, OrsoIRCSS Fdn Ist Neurol Carlo Besta, Div Neuropathol & Neurol 5, Milan, Italy (author)
  • Ferrer, IsidroUniv Barcelona, CEBERNED, Bellvitge Univ Hosp, Inst Neuropathol, Barcelona, Spain (author)
  • Gelpi, EllenBiobanc Hosp Clin IDIBAPS, Neurol Tissue Bank, Barcelona, Spain (author)
  • Gentleman, StephenUniv London Imperial Coll Sci Technol & Med, Dept Med, Neuropathol Unit, London, England (author)
  • Giaccone, GiorgioIRCSS Fdn Ist Neurol Carlo Besta, Div Neuropathol & Neurol 5, Milan, Italy (author)
  • Graeber, Manuel B.Univ Sydney, Fac Med, Sydney, NSW 2006, Australia; Univ Sydney, Fac Hlth Sci, Brain & Mind Res Inst, Sydney, NSW 2006, Australia (author)
  • Hortobagyi, TiborUniv Debrecen, Instutute Pathol, Dept Neuropathol, Debrecen, Hungary (author)
  • Ince, Paul G.Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England (author)
  • Ironside, James W.Univ Edinburgh, Western Gen Hosp, Natl CJD Res & Surveillance Unit, Edinburgh, Midlothian, Scotland (author)
  • Kavantzas, NikolaosNatl & Capodistrian Univ Athens, Dept Pathol, Athens, Greece (author)
  • King, AndrewKings Coll Hosp London, Inst Psychiat, Dept Clin Neuropathol, London, England; MRC, London Neurodegenerat Dis Brain Bank, London, England (author)
  • Korkolopoulou, PenelopeNatl & Capodistrian Univ Athens, Dept Pathol, Athens, Greece (author)
  • Kovács, Gábor G.Med Univ Vienna, Inst Neurol, Vienna, Austria (author)
  • Meyronet, DavidUniv Lyon, Hosp Civils Lyon, Ctr Pathol & Neuropathol Est, Lyon Neurosci Res Ctr, Lyon, France (author)
  • Monoranu, CameliaUniv Wurzburg, Abt Neuropathol, Pathol Inst, D-97070 Wurzburg, Germany (author)
  • Nilsson, TatjanaKarolinska Inst, Dept Geriatr, Stockholm, Sweden (author)
  • Parchi, PieroUniv Bologna, Ist Sci Neurol, Dept Biomed & Neuromotor Sci, IRCCS, Bologna, Italy (author)
  • Patsouris, EfstratiosNatl & Capodistrian Univ Athens, Dept Pathol, Athens, Greece (author)
  • Revesz, TamasUCL Inst Neurol, Queen Sq Brain Bank, Dept Mol Neurosci, London, England (author)
  • Roggendorf, WolfgangUniv Wurzburg, Abt Neuropathol, Pathol Inst, D-97070 Wurzburg, Germany (author)
  • Rozemuller, AnnemiekeVrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands (author)
  • Seilhean, DanielleUniv Paris 06, AP HP, Lab Neuropathol Raymond Escourolle, Paris, France; INSERM, Paris, France (author)
  • Streichenberger, NathalieUniv Lyon, Hosp Civils Lyon, Ctr Pathol & Neuropathol Est, Lyon Neurosci Res Ctr, Lyon, France (author)
  • Thal, Dietmar R.Univ Ulm, Inst Pathol, Neuropathol Lab, D-89069 Ulm, Germany (author)
  • Wharton, Stephen B.Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England (author)
  • Kretzschmar, HansUniv Munich, Ctr Neuropathol & Prion Res, Munich, Germany (author)
  • Uppsala universitetInstitutionen för immunologi, genetik och patologi (creator_code:org_t)

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  • In:Journal of neural transmission: Springer Science and Business Media LLC122:7, s. 957-9720300-95641435-1463

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