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Prognostic Factors ...
Prognostic Factors and Risk Groups in T1G3 Non-Muscle-invasive Bladder Cancer Patients Initially Treated with Bacillus Calmette-Guerin : Results of a Retrospective Multicenter Study of 2451 Patients
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Gontero, Paolo (author)
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Sylvester, Richard (author)
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Pisano, Francesca (author)
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Joniau, Steven (author)
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Eeckt, Kathy Vander (author)
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Serretta, Vincenzo (author)
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Larre, Stephane (author)
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Di Stasi, Savino (author)
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Van Rhijn, Bas (author)
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Witjes, Alfred J. (author)
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Grotenhuis, Anne J. (author)
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Kiemeney, Lambertus A. (author)
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Colombo, Renzo (author)
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Briganti, Alberto (author)
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Babjuk, Marek (author)
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- Malmström, Per-Uno (author)
- Uppsala universitet,Urologkirurgi
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Oderda, Marco (author)
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Irani, Jacques (author)
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Malats, Nuria (author)
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Baniel, Jack (author)
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Mano, Roy (author)
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Cai, Tommaso (author)
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Cha, Eugene K. (author)
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Ardelt, Peter (author)
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Varkarakis, John (author)
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Bartoletti, Riccardo (author)
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Spahn, Martin (author)
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- Johansson, Robert (author)
- Umeå universitet,Onkologi
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Frea, Bruno (author)
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Soukup, Viktor (author)
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Xylinas, Evanguelos (author)
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Dalbagni, Guido (author)
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Karnes, R. Jeffrey (author)
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Shariat, Shahrokh F. (author)
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Palou, Joan (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 67:1, s. 74-82
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: The impact of prognostic factors in T1G3 non-muscle-invasive bladder cancer (BCa) patients is critical for proper treatment decision making. Objective: To assess prognostic factors in patients who received bacillus Calmette Guerin (BCG) as initial intravesical treatment of T1G3 tumors and to identify a subgroup of high-risk patients who should be considered for more aggressive treatment. Design, setting, and participants: Individual patient data were collected for 2451 T1G3 patients from 23 centers who received BCG between 1990 and 2011. Outcome measurements and statistical analysis: Using Cox multivariable regression, the prognostic importance of several clinical variables was assessed for time to recurrence, progression, BCa-specific survival, and overall survival (OS). Results and limitations: With a median follow-up of 5.2 yr, 465 patients (19%) progressed, 509 (21%) underwent cystectomy, and 221 (9%) died because of BCa. In multivariable analyses, the most important prognostic factors for progression were age, tumor size, and concomitant carcinoma in situ (CIS); the most important prognostic factors for BCa-specific survival and OS were age and tumor size. Patients were divided into four risk groups for progression according to the number of adverse factors among age >= 70 yr, size >= 3 cm, and presence of CIS. Progression rates at 10 yr ranged from 17% to 52%. BCa-specific death rates at 10 yr were 32% in patients >= 70 yr with tumor size >= 3 cm and 13% otherwise. Conclusions: T1G3 patients >= 70 yr with tumors >= 3 cm and concomitant CIS should be treated more aggressively because of the high risk of progression. Patient summary: Although the majority of T1G3 patients can be safely treated with intravesical bacillus Calmette-Guerin, there is a subgroup of T1G3 patients with age >= 70 yr, tumor size >= 3 cm, and concomitant CIS who have a high risk of progression and thus require aggressive treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Bacillus Calmette-Guerin
- BCG
- Non-muscle-invasive bladder cancer
- Prognostic factors
- T1G3
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gontero, Paolo
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Sylvester, Richa ...
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Pisano, Francesc ...
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Joniau, Steven
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Eeckt, Kathy Van ...
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Serretta, Vincen ...
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show more...
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Larre, Stephane
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Di Stasi, Savino
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Van Rhijn, Bas
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Witjes, Alfred J ...
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Grotenhuis, Anne ...
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Kiemeney, Lamber ...
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Colombo, Renzo
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Briganti, Albert ...
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Babjuk, Marek
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Malmström, Per-U ...
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Oderda, Marco
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Irani, Jacques
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Malats, Nuria
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Baniel, Jack
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Mano, Roy
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Cai, Tommaso
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Cha, Eugene K.
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Ardelt, Peter
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Varkarakis, John
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Bartoletti, Ricc ...
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Spahn, Martin
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Johansson, Rober ...
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Frea, Bruno
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Soukup, Viktor
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Xylinas, Evangue ...
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Dalbagni, Guido
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Karnes, R. Jeffr ...
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Shariat, Shahrok ...
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Palou, Joan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Urology
- By the university
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Uppsala University
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Umeå University