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1p36 deletion is a ...
1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer
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- Mayrhofer, Markus (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin
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- Kultima, Hanna Göransson (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin
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- Birgisson, Helgi (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Kolorektalkirurgi
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- Sundström, Magnus (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär och morfologisk patologi
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- Mathot, Lucy (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik
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- Edlund, Karolina (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för radiologi, onkologi och strålningsvetenskap
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- Viklund, Björn (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin
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- Sjöblom, Tobias (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik
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- Botling, Johan (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär och morfologisk patologi
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- Micke, Patrick (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär och morfologisk patologi
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- Påhlman, Lars (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Kolorektalkirurgi
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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- Isaksson, Anders (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin
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(creator_code:org_t)
- 2014-11-24
- 2014
- English.
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In: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 14, s. 872-
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://bmccancer.bi...
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Abstract
Subject headings
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- Background: The clinical behaviour of colon cancer is heterogeneous. Five-year overall survival is 50-65% with all stages included. Recurring somatic chromosomal alterations have been identified and some have shown potential as markers for dissemination of the tumour, which is responsible for most colon cancer deaths. We investigated 115 selected stage II-IV primary colon cancers for associations between chromosomal alterations and tumour dissemination. Methods: Follow-up was at least 5 years for stage II-III patients without distant recurrence. Affymetrix SNP 6.0 microarrays and allele-specific copy number analysis were used to identify chromosomal alterations. Fisher's exact test was used to associate alterations with tumour dissemination, detected at diagnosis (stage IV) or later as recurrent disease (stage II-III). Results: Loss of 1p36.11-21 was associated with tumour dissemination in microsatellite stable tumours of stage II-IV (odds ratio = 5.5). It was enriched to a similar extent in tumours with distant recurrence within stage II and stage III subgroups, and may therefore be used as a prognostic marker at diagnosis. Loss of 1p36.11-21 relative to average copy number of the genome showed similar prognostic value compared to absolute loss of copies. Therefore, the use of relative loss as a prognostic marker would benefit more patients by applying also to hyperploid cancer genomes. The association with tumour dissemination was supported by independent data from the The Cancer Genome Atlas. Conclusion: Deletions on 1p36 may be used to guide adjuvant treatment decisions in microsatellite stable colon cancer of stages II and III.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Colon cancer
- Prognostic marker
- Allele-specific copy number analysis
- Genome duplication
- 1p36
- Metastasis
- Tumour dissemination
Publication and Content Type
- ref (subject category)
- art (subject category)
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BMC Cancer
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- By the author/editor
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Mayrhofer, Marku ...
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Kultima, Hanna G ...
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Birgisson, Helgi
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Sundström, Magnu ...
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Mathot, Lucy
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Edlund, Karolina
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show more...
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Viklund, Björn
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Sjöblom, Tobias
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Botling, Johan
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Micke, Patrick
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Påhlman, Lars
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Glimelius, Bengt
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Isaksson, Anders
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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BMC Cancer
- By the university
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Uppsala University