Search: onr:"swepub:oai:DiVA.org:uu-242386" >
Antigen Conjugated ...
Antigen Conjugated to Anti-CD23 Antibodies is Rapidly Transported to Splenic Follicles by Recirculating B Cells
-
- Xu, Hui (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
- van Mechelen, Lenny (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
- Henningsson, Frida (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
show more...
-
- Heyman, Birgitta (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
show less...
-
(creator_code:org_t)
- 2014-12-23
- 2015
- English.
-
In: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 81:1, s. 39-45
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- IgE-antigen complexes, administered intravenously to mice, induce a several 100-fold higher specific antibody response than antigen alone. Additionally, in vivo activation and proliferation of specific CD4(+) T cells is enhanced. The mechanism behind these effects is thought to be that peripheral B cells capture IgE-antigen complexes via their low-affinity receptor for IgE, CD23, and rapidly transport them to splenic B cell follicles where an immune response is initiated. Here, we demonstrate that ovalbumin, covalently coupled to anti-CD23 antibodies and administered intravenously to mice, is also transported to splenic follicles and induces an enhanced primary antibody response. These effects are absent in CD23-deficient mice. No enhanced induction of immunological memory was observed. These findings extend previous observations regarding the in vivo role of CD23 and emphasize that recirculating B cells play an important role in antigen transport to the spleen.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database