onr:"swepub:oai:DiVA.org:uu-243450"
Search: onr:"swepub:oai:DiVA.org:uu-243450" > The use of hydrogen...
- 1 of 1
- Previous record
- Next record
- To hitlist
The use of hydrogen gas clearance for blood flow measurements in single endogenous and transplanted pancreatic islets
-
- Barbu, Andreea (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala University, Sweden; Uppsala University, Sweden
-
- Jansson, Leif (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala University, Sweden
-
- Sandberg, Monica (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala University, Sweden
- show more...
- show less...
- (creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
- In: Microvascular Research. - : Elsevier BV. - 0026-2862 .- 1095-9319. ; 97, s. 124-129
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The blood perfusion of pancreatic islets is regulated independently from that of the exocrine pancreas, and is of importance for multiple aspects of normal islet function, and probably also during impaired glucose tolerance. Single islet blood flow has been difficult to evaluate due to technical limitations. We therefore adapted a hydrogen gas washout technique using microelectrodes to allow such measurements. Platinum micro-electrodes monitored hydrogen gas clearance from individual endogenous and transplanted islets in the pancreas of male Lewis rats and in human and mouse islets implanted under the renal capsule of male athymic mice. Both in the rat endogenous pancreatic islets as well as in the intra-pancreatically transplanted islets, the vascular conductance and blood flow values displayed a highly heterogeneous distribution, varying by factors 6-10 within the same pancreas. The blood flow of human and mouse islet grafts transplanted in athymic mice was approximately 30% lower than that in the surrounding renal parenchyma. The present technique provides unique opportunities to study the islet vascular dysfunction seen after transplantation, but also allows for investigating the effects of genetic and environmental perturbations on islet blood flow at the single islet level in vivo. (C) 2014 The Authors. Published by Elsevier Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Blood flow
- Hydrogen gas washout
- Pancreatic islets
- Transplanted islets
- In vivo
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Microvascular Research (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Barbu, Andreea
- Jansson, Leif
- Sandberg, Monica
- Quach, My
- Palm, Fredrik
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Medical Biotechn ...
- and Medical Biotechn ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- Articles in the publication
- Microvascular Re ...
- By the university
- Uppsala University
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
