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Alkaline phosphatas...
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Ridefelt, PeterUppsala universitet,Biokemisk struktur och funktion
(author)
Alkaline phosphatase in healthy children : reference intervals and prevalence of elevated levels.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-12-18
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S. Karger AG,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-244228
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244228URI
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https://doi.org/10.1159/000369205DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Transient hyperphosphatasemia (TH) is an often unnoticed benign entity, primarily affecting children below 5 years of age. However, the prevalence among healthy children is unknown. We used data from a Swedish pediatric reference interval project to estimate the prevalence of high alkaline phosphatase (ALP) among healthy children and to calculate pediatric reference intervals.METHODS: Blood was collected from 699 subjectively healthy children aged 6 months to 18 years. After exclusion of subjects with high ALP, age- and gender-specific reference intervals were calculated.RESULTS: Six children had ALP levels >16.7 µkat/l (>1,000 U/l), including 4 females and 2 males aged 7-22 months. The prevalence in the age group from 6 months to 2 years was 6.2% (6/97). None of the older children had levels of ALP >16.7 µkat/l. The study did not include the follow-up of these apparently healthy children. Consequently, conditions others than TH explaining the elevated ALP could not be excluded. However, general chemistry analyses, such as liver enzymes, calcium, intact PTH and vitamin D, were essentially normal in these children.CONCLUSIONS: The prevalence of high ALP among subjectively healthy children was approximately 2.4% below 5 years of age and 6.2% below 2 years. Reference intervals vary with age and gender.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Gustafsson, Jan,1948-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson(Swepub:uu)jangfs
(author)
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Aldrimer, Mattias
(author)
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Hellberg, Dan,1953-Uppsala universitet,Centrum för klinisk forskning Dalarna,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa(Swepub:uu)dahel227
(author)
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Uppsala universitetBiokemisk struktur och funktion
(creator_code:org_t)
Related titles
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In:Hormone Research in Paediatrics: S. Karger AG82:6, s. 399-4041663-28181663-2826
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