Search: onr:"swepub:oai:DiVA.org:uu-244483" > Combined MYC and P5...
Fältnamn | Indikatorer | Metadata |
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000 | 03712naa a2200697 4500 | |
001 | oai:DiVA.org:uu-244483 | |
003 | SwePub | |
008 | 150217s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2444832 URI |
024 | 7 | a https://doi.org/10.1016/j.ccell.2014.11.0022 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hill, Rebecca M.4 aut |
245 | 1 0 | a Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease |
264 | 1 | b Elsevier BV,c 2015 |
338 | a electronic2 rdacarrier | |
520 | a We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this group died of rapidly progressive disease postrelapse. To study this interaction, we investigated a transgenic model of MYCN-driven medulloblastoma and found spontaneous development of Trp53 inactivating mutations. Abrogation of p53 function in this model produced aggressive tumors that mimicked characteristics of relapsed human tumors with combined P53-MYC dysfunction. Restoration of p53 activity and genetic and therapeutic suppression of MYCN all reduced tumor growth and prolonged survival. Our findings identify P53-MYC interactions at medulloblastoma relapse as biomarkers of clinically aggressive disease that may be targeted therapeutically. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
700 | 1 | a Kuijper, Sanne4 aut |
700 | 1 | a Lindsey, Janet C.4 aut |
700 | 1 | a Petrie, Kevin4 aut |
700 | 1 | a Schwalbe, Ed C.4 aut |
700 | 1 | a Barker, Karen4 aut |
700 | 1 | a Boult, Jessica K. R.4 aut |
700 | 1 | a Williamson, Daniel4 aut |
700 | 1 | a Ahmad, Zai4 aut |
700 | 1 | a Hallsworth, Albert4 aut |
700 | 1 | a Ryan, Sarra L.4 aut |
700 | 1 | a Poon, Evon4 aut |
700 | 1 | a Robinson, Simon P.4 aut |
700 | 1 | a Ruddle, Ruth4 aut |
700 | 1 | a Raynaud, Florence I.4 aut |
700 | 1 | a Howell, Louise4 aut |
700 | 1 | a Kwok, Colin4 aut |
700 | 1 | a Joshi, Abhijit4 aut |
700 | 1 | a Nicholson, Sarah Leigh4 aut |
700 | 1 | a Crosier, Stephen4 aut |
700 | 1 | a Ellison, David W.4 aut |
700 | 1 | a Wharton, Stephen B.4 aut |
700 | 1 | a Robson, Keith4 aut |
700 | 1 | a Michalski, Antony4 aut |
700 | 1 | a Hargrave, Darren4 aut |
700 | 1 | a Jacques, Thomas S.4 aut |
700 | 1 | a Pizer, Barry4 aut |
700 | 1 | a Bailey, Simon4 aut |
700 | 1 | a Swartling, Fredrik J.u Uppsala universitet,Neuroonkologi4 aut0 (Swepub:uu)fredjoha |
700 | 1 | a Weiss, William A.4 aut |
700 | 1 | a Chesler, Louis4 aut |
700 | 1 | a Clifford, Steven C.4 aut |
710 | 2 | a Uppsala universitetb Neuroonkologi4 org |
773 | 0 | t Cancer Celld : Elsevier BVg 27:1, s. 72-84q 27:1<72-84x 1535-6108x 1878-3686 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:790743/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.cell.com/article/S153561081400453X/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244483 |
856 | 4 8 | u https://doi.org/10.1016/j.ccell.2014.11.002 |
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