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FcγRIIb on myeloid ...
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Yilmaz-Elis, A Seda
(author)
FcγRIIb on myeloid cells rather than on B cells protects from collagen-induced arthritis
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-06-15
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The American Association of Immunologists,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-245260
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-245260URI
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https://doi.org/10.4049/jimmunol.1303272DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Extensive analysis of a variety of arthritis models in germline KO mice has revealed that all four receptors for the Fc part of IgG (FcγR) play a role in the disease process. However, their precise cell type-specific contribution is still unclear. In this study, we analyzed the specific role of the inhibiting FcγRIIb on B lymphocytes (using CD19Cre mice) and in the myeloid cell compartment (using C/EBPαCre mice) in the development of arthritis induced by immunization with either bovine or chicken collagen type II. Despite their comparable anti-mouse collagen autoantibody titers, full FcγRIIb knockout (KO), but not B cell-specific FcγRIIb KO, mice showed a significantly increased incidence and severity of disease compared with wild-type control mice when immunized with bovine collagen. When immunized with chicken collagen, disease incidence was significantly increased in pan-myeloid and full FcγRIIb KO mice, but not in B cell-specific KO mice, whereas disease severity was only significantly increased in full FcγRIIb KO mice compared with incidence and severity in wild-type control mice. We conclude that, although anti-mouse collagen autoantibodies are a prerequisite for the development of collagen-induced arthritis, their presence is insufficient for disease development. FcγRIIb on myeloid effector cells, as a modulator of the threshold for downstream Ab effector pathways, plays a dominant role in the susceptibility to collagen-induced arthritis, whereas FcγRIIb on B cells, as a regulator of Ab production, has a minor effect on disease susceptibility.
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Ramirez, Javier Martin
(author)
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Asmawidjaja, Patrick
(author)
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van der Kaa, Jos
(author)
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Mus, Anne-Marie
(author)
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Brem, Maarten D
(author)
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Claassens, Jill W C
(author)
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Breukel, Cor
(author)
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Brouwers, Conny
(author)
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Mangsbo, Sara MDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands,Tötterman(Swepub:uu)saman132
(author)
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Boross, Peter
(author)
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Lubberts, Erik
(author)
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Verbeek, J Sjef
(author)
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Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsTötterman
(creator_code:org_t)
Related titles
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In:Journal of Immunology: The American Association of Immunologists192:12, s. 5540-55470022-17671550-6606
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Yilmaz-Elis, A S ...
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Ramirez, Javier ...
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Asmawidjaja, Pat ...
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van der Kaa, Jos
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Mus, Anne-Marie
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Brem, Maarten D
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Claassens, Jill ...
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Breukel, Cor
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Brouwers, Conny
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Mangsbo, Sara M
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Boross, Peter
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Lubberts, Erik
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Verbeek, J Sjef
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- MEDICAL AND HEALTH SCIENCES
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Uppsala University