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  • Yilmaz-Elis, A Seda (author)

FcγRIIb on myeloid cells rather than on B cells protects from collagen-induced arthritis

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-06-15
  • The American Association of Immunologists,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-245260
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-245260URI
  • https://doi.org/10.4049/jimmunol.1303272DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Extensive analysis of a variety of arthritis models in germline KO mice has revealed that all four receptors for the Fc part of IgG (FcγR) play a role in the disease process. However, their precise cell type-specific contribution is still unclear. In this study, we analyzed the specific role of the inhibiting FcγRIIb on B lymphocytes (using CD19Cre mice) and in the myeloid cell compartment (using C/EBPαCre mice) in the development of arthritis induced by immunization with either bovine or chicken collagen type II. Despite their comparable anti-mouse collagen autoantibody titers, full FcγRIIb knockout (KO), but not B cell-specific FcγRIIb KO, mice showed a significantly increased incidence and severity of disease compared with wild-type control mice when immunized with bovine collagen. When immunized with chicken collagen, disease incidence was significantly increased in pan-myeloid and full FcγRIIb KO mice, but not in B cell-specific KO mice, whereas disease severity was only significantly increased in full FcγRIIb KO mice compared with incidence and severity in wild-type control mice. We conclude that, although anti-mouse collagen autoantibodies are a prerequisite for the development of collagen-induced arthritis, their presence is insufficient for disease development. FcγRIIb on myeloid effector cells, as a modulator of the threshold for downstream Ab effector pathways, plays a dominant role in the susceptibility to collagen-induced arthritis, whereas FcγRIIb on B cells, as a regulator of Ab production, has a minor effect on disease susceptibility.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Ramirez, Javier Martin (author)
  • Asmawidjaja, Patrick (author)
  • van der Kaa, Jos (author)
  • Mus, Anne-Marie (author)
  • Brem, Maarten D (author)
  • Claassens, Jill W C (author)
  • Breukel, Cor (author)
  • Brouwers, Conny (author)
  • Mangsbo, Sara MDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands,Tötterman(Swepub:uu)saman132 (author)
  • Boross, Peter (author)
  • Lubberts, Erik (author)
  • Verbeek, J Sjef (author)
  • Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsTötterman (creator_code:org_t)

Related titles

  • In:Journal of Immunology: The American Association of Immunologists192:12, s. 5540-55470022-17671550-6606

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