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Hepatitis A vaccine...
Hepatitis A vaccine for immunosuppressed patients with rheumatoid arthritis : a prospective, open-label, multi-centre study
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- Askling, Helena H. (author)
- Karolinska Institutet
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- Rombo, Lars (author)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Med Solna, Infect Dis Unit, SE-17176 Stockholm, Sweden
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- van Vollenhoven, Ronald (author)
- Karolinska Institutet
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- Hallén, Ingemar (author)
- Karlstad Cty Hosp, Dept Infect Dis, SE-65185 Karlstad, Sweden
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- Thörner, Åke (author)
- Malar Hosp, Dept Rheumatol, SE-63188 Eskilstuna, Sweden
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- Nordin, Margareta (author)
- Karolinska Univ Hosp, Dept Clin Microbiol, SE-17176 Stockholm, Sweden
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- Herzog, Christian (author)
- Swiss Trop & Publ Hlth Inst, CH-4051 Basel, Switzerland
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- Kantele, Anu (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Travel Medicine and Infectious Disease. - : Elsevier BV. - 1477-8939 .- 1873-0442. ; 12:2, s. 134-42
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: Hepatitis A vaccine is the most frequently used travel vaccine, yet data are scarce about its ability to induce protection in patients with concurrent immunosuppressive treatment. We assessed the immunogenicity of this vaccine in rheumatoid arthritis (RA) patients treated with tumour necrosis factor-inhibitors (TNFi) and/or methotrexate (MTX).METHODS: Hepatitis A vaccine was administered to non-immune RA patients at 0 and 6 months. Hepatitis A virus (HAV) antibodies were assessed at 0, 1, 6, 7, 12, and 24 months with a quantitative Chemiluminescent Microparticle Immuno Assay (CMIA) for HAV-IgG. Samples from month 1, 6, and 7 were, in addition, analysed with a microparticle EIA (MEIA) for anti-HAV IgM + IgG.RESULTS: The final study population consisted of 53 patients treated with TNFi (n = 15), TNFi + MTX (n = 21) or MTX (n = 17). One and six months after the first dose, 10% and 33% of the patients had attained seroprotection. One and six months after the second dose 83% and 72% were seroprotected. At month 24, 86% of the vaccinees showed protective levels.CONCLUSIONS: Two doses of hepatitis A vaccine at a 6-month interval provided protection for most immunosuppressed RA patients. A single dose does not seem to afford sufficient protection to this group of patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Hepatitis A
- Vaccination
- Immunosuppression
- Rheumatoid arthritis
- TNF-inhibitors
Publication and Content Type
- ref (subject category)
- art (subject category)
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